2种检测方法对不同年龄组涂阴肺结核病诊断价值的对比分析

Comparative analysis of the diagnostic value of smear negative pulmonary tuberculosis in different age groups by two methods

目的探讨γ干扰素释放试验（T-SPOT.TB）及结核蛋白芯片检测对不同年龄组抗酸染色涂片阴性肺结核病的诊断价值。方法分别选取已确诊的涂阴肺结核病例191例、肺炎病例91例,分为3组：青少年组（7~40岁）,中年组（〉40~65岁）,老年组（〉65岁）,均进行T-SPOT.TB及结核蛋白芯片检测。结果青少年组和中年组2种检测方法敏感度差异有统计学意义（P〈0.05）、特异性差异无统计学意义（P〉0.05）,而老年组敏感度、特异度差异均无统计学意义（P〉0.05）。结论 T-SPOT.TB方法对青少年及中年涂阴肺结核的诊断有一定的价值,对老年涂阴肺结核的诊断则应视具体情况选择。

Objective To evaluate the diagnostic value of T-SPOT.TB and tuberculosis protein chip test for difference age patients with smear-negative pulmonary tuberculosis.Methods One hundred and ninety-one tuberculosis patients（smear-negative pulmonary tuberculosis）and91pneumonia patients were enrolled in our test.They were divided into three groups：the teenage group（7~40years old）,the middle-aged group（40~65years old）and the gerontism group（more than 65years old）.The three groups were examined with T-SPOT.TB and tuberculosis protein chip test.Results The sensitivity of T-SPOT.TB and tuberculosis protein chip test in teenage group and middle-aged group were significant difference between the two methods（P〈0.05）,but the specificity of two methods was no significant difference（P〉0.05）.The sensitivity and specificity in gerontism group were no significant difference（P〉0.05）.Conclusion TSPOT.TB was important in the diagnosis for teenage and middle-aged patients with smearnegative pulmonary tuberculosis.The diagnosis of smear negative pulmonary tuberculosis in the elder patients should be selected according to the specific status.