瓜菜类病原细菌耐药外排泵RND研究进展

Advances in RND-type multi-drug efflux pumps from cucurbit and vegetable pathogenic bacteria

近年来,瓜菜类作物病原细菌的耐药性日益增强,增加了瓜菜相关病害防治的难度。存在于瓜菜作物病原细菌中的外排泵耐药结节分化家族(RND)与细菌的耐药性及细菌/植物互作关系密切。笔者根据有关文献综述了RND外排泵的结构与功能、细菌/植物互作过程中外排泵的作用以及外排泵抑制剂(EPIS)的相关研究进展,为瓜类和蔬菜类作物病原细菌耐药性的研究提供参考。

In recent years, drug resistance of bacteria causing diseases on cucurbits and vegetables has been increasingly reported which caused huge difficluties in cucurbit and vegetable prevention. Resistance-nodulation-division family（RND） is one of the most important efflux pump family in cucurbit and vegetable pathogenic bacteria, which is closely related to bacteria multidrug resistance and interactions between pathogenic bacteria and plants. We describe structures and functions of RND efflux pumps, relationships between efflux pumps and bacterial/plant interactions as well as the relevant research of efflux pump inhibitors（EPIS）. This review will provide references for further studies on drug resistance of cucurbit and vegetable pathogenic bacteria.