嘌呤能受体P2X对痛性糖尿病神经病变的调控作用

The role of P2X receptors in painful diabetic neuropathy

痛性糖尿病神经病变（PDN）是糖尿病周围神经病变（DPN）的常见临床表现之一.目前PDN的发病机制尚不明确,现有的治疗方案有限且疗效欠佳.在初级传入感觉神经系统,P2X3受体在小直径背根神经节（DRG）神经元选择性高表达,高血糖通过诱导P2X3受体可塑性的改变来调控对疼痛的反应.在1型糖尿病模型小鼠中,P2X7受体可能通过调节神经递质的释放,使糖尿病小鼠产生机械痛敏.此外,也有研究报道其他P2X受体如P2X2、P2X4参与对PDN的调控.设计针对P2X受体的药物,可能是一种新的个体化治疗PDN的有效方法.

Painful diabetic neuropathy （PDN） is one of the most common clinic manifestation of diabetic peripheral neuropathy （DPN）.The pathogenesis of PDN is not fully understood and current treatment options are limited and not satisfying.P2X3 receptor mostly expresses in the small-diameter dorsal root ganglion （DRG） neurons in primary afferent sensory nerve system.Hyperglycemia induces the change of P2X3 receptor＇s plasticity to adjust pain responses.In type 1 diabetes mellitus model mice,P2X7 receptor makes the diabetic mice produce mechanical pain sensitivity by releasing neurotransmitters.What＇s more,it has been reported that other P2X receptors such as P2X2 and P2X4 are involved in the regulation of PDN.Designing drugs against P2X receptors may be a new effective method of individualized treatment of PDN.