瑞舒伐他汀治疗冠心病急性心肌梗死的效果

Effect of Rosuvastatin in the treatment of patients with acute myocardial infarction of coronary heart disease

目的探讨瑞舒伐他汀治疗冠心病急性心肌梗死的临床效果。方法将2013年12月~2015年6月河北友爱医院收治的96例冠心病急性心肌梗死患者随机分为观察组和对照组,各48例。对照组采用常规治疗,观察组在常规治疗基础上加用瑞舒伐他汀治疗。比较两组治疗前后左心室射血分数（LVEF）、血管内皮扩张功能（FMD）、C反应蛋白（CRP）、总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）及血液流变学水平。结果两组治疗后LVEF、FMD、CRP均较治疗前明显改善（P〈0.05）,且观察组治疗后LVEF、FMD水平高于对照组,CRP水平低于对照组,差异均有统计学意义（P〈0.05）。两组治疗后血脂水平均较治疗前明显改善（P〈0.05）,且观察组治疗后TC、TG、LDL-C水平低于对照组,HDL-C水平高于对照组,差异均有统计学意义（P〈0.05）。两组治疗后血液流变学指标均较治疗前明显改善（P〈0.05）,且观察组治疗后全血高切黏度、全血低切黏度、血浆黏度及纤维蛋白原水平明显低于对照组,差异均有统计学意义（P〈0.05）。两组患者治疗期间预后良好,仅对照组出现1例复发性心绞痛。结论瑞舒伐他汀治疗冠心病急性心肌梗死有助于改善心功能和内皮功能,可调节血脂,抑制炎性反应,改善血液流变学,效果显著,值得在临床上推广。

Objective To investigate the clinical effect of Rosuvastatin in the treatment of patients with acute myocardial infarction of coronary heart disease. Methods Ninety six cases of patients with acute myocardial infarction of coronary heart disease admitted to Hebei Friendship Hospital from December 2013 to June 2015 were randomly divided into observation group and control group, with 48 cases in each group. The control group was treated with routine treatment, and the observation group was treated with Rosuvastatin on basis of the conventional therapy. The levels of left ventricular ejection fraction（LVEF）, flow-mediated dilation（FMD）, C-reactive protein（CRP）, total cholesterol（TC）, triacylglycerol（TG）, low density lipoprotein cholesterin（LDL-C）, high density lipoprotein cholesterol（HDL-C） and hemorheology of the two groups before and after treatment were compared. Results The levels of LVEF, FMD, CRP of the two groups after treatment were significantly improved compared with those before treatment（P〈 0.05）, and the levels of FMD, LVEF of the observation group after treatment were higher than those of control group, the level of CRP was lower than that of control group, the differences were statistically significant（P〈 0.05）; the levels of blood lipid of the two groups after treatment were significantly improved compared with those before treatment（P〈 0.05）, and the levels of TC, TG, LDL-C of the observation group after treatment were lower than those of control group, the level of HDL-C was higher than that of control group, the differences were statistically significant（P〈 0.05）; the hemorheology indexes of the two groups after treatment were significantly improved compared with those before treatment, and the levels of high blood viscosity, low blood viscosity, plasma viscosity and fibrinogen of the observation group after treatment were lower than those of control group, the differences were statistically significant（P〈 0.05）. The patients of the two groups had favourable prognosis during the treatment, there was only one recurrent angina in the control group.Conclusion Rosuvastatin in the treatment of patients with acute myocardial infarction of coronary heart disease is helpful to improve the cardiac function and endothelial function, which can regulate blood-lipid, inhibit inflammatory reactio n, improve the hemorheology, with significant effects,it is worthy of clinical promotion.