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转录协同激活因子Yes相关蛋白与卵巢癌发生的研究进展 被引量：2

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摘要 转录协同激活因子Yes相关蛋白(YAP)是Hippo信号通路最主要的效应因子,位于染色体11q22扩增区上,相对分子量为65 Kda,大量研究发现,YAP在卵巢癌中高表达,且具有促进卵巢癌细胞增殖、抑制凋亡、产生耐药性、维持卵巢癌干细胞多潜能性的作用。随着对YAP研究的深入,发现多种因素共同参与调节YAP介导的卵巢癌进展,其中包括溶血磷脂酸(LPA)和表皮生长因子受体(EGFR)参与信号通路间的相互协作,以及微小RNA(miRNA)的miR-129-5p在转录水平上通过直接靶向调控YAP基因,进而影响卵巢癌的发生发展。研究显示靶向YAP有望成为卵巢癌的治疗手段,下调YAP表达或许成为治疗卵巢癌的新策略。
作者 冯君桃 勾金海 贾佳 李征宇
机构地区 四川大学华西第二医院四川省妇科肿瘤重点实验室
出处 《实用妇产科杂志》 CAS CSCD 北大核心 2016年第6期420-423,共4页 Journal of Practical Obstetrics and Gynecology
基金 四川省青年科技基金(编号:2015JQ0026)
关键词 Hippo信号通路 Yes相关蛋白 卵巢癌 溶血磷脂酸 表皮生长因子受体 miR-129-5p
分类号 R737.31 [医药卫生—肿瘤]
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参考文献27

  • 1Santucci M, Vignudelli T, Ferrari S, et al. The Hippo pathway andYAP/TAZ-TEAD protein-protein interaction as targets for regenera-tive medicine and cancer treatment[ J]. J Med Chem,2015 ,58( 12):4857 -4873.
  • 2Barron DA,Kagey JD. The role of the Hippo pathway in human dis-ease and tumorigenesis[ J]. Clin Transl Med,2014 ,3 :25.
  • 3Sudol M,Chen HI,Bougeret C, et al. Characterization of a novel pro-tein-binding module-the WW domain[ J]. FEBS Lett, 1995 ,369( 1):67 -71.
  • 4Sudol M, Shields DC, Farooq A. Structures of YAP protein domainsreveal promising targets for development of new cancer drugs[ J]. Se-min Cell Dev Biol,2012,23(7) :827 -833.
  • 5Zhao B,Lei QY,Guan KL. The Hippo-YAP pathway : new connectionsbetween regulation of organ size and cancer[ J ]. Curr Opin Cell Biol,2008,20(6) :638 -646.
  • 6Yagi R, Chen LF, Shigesada K, et al. A WW domain-containingyes-associated protein( YAP) is a novel transcriptional co-activator[J].EMBO J,1999,18(9) :2551 -2562.
  • 7Komuro A,Nagai M,Navin NE,et al. WW domain-containing proteinYAP associates with ErbB-4 and acts as a co-transcriptional activatorfor the carboxyl-terminal fragment of ErbB-4 that translocates to thenucleus [ J ]. J Biol Chem, 2003 ,278(35) :33334 - 33341.
  • 8Strano S,Munarriz E,Rossi M,et al. Physical interaction with Yes-associ-ated protein enhances p73 transcriptional activity[ J]. J Biol Chem,2001,276(18):15164-15173.
  • 9Lau AN, Curtis SJ , Fillmore CM, et al. Tumor-propagating cells andYap/Taz activity contribute to lung tumor progression and metastasis[J], EMBO J,2014,33(5) :468 -481.
  • 10Xu CM, Liu WW, Liu CJ, et al. Mstl overexpression inhibited thegrowth of human non-small cell lung cancer in vitro and in vivo[ J ].Cancer Gene Ther,2013 ,20(8) :453 -460.

二级参考文献16

  • 1Jaramillo MC, Zhang DD. The emerging role of the Nrf2-Keaplsignaling pathway in cancer[J]. Genes Dev,2013,27(20) :2179-2191.
  • 2Liu AM, Xu Z,Luk JM. An update on targeting Hippo-YAPsignaling in liver cancer[J]. Expert Opin Ther Targets, 2012,16(3):243-247.
  • 3Barry ER, Camargo FD. The Hippo superhighway; signaling cross-roads converging on the Hippo/Yap pathway in stem cells and devel-opment[J], Curr Opin Cell liiol’2013,25(2) :247-253.
  • 4Zhao Li L, Lei Q,et al. The Hippo-YAP pathway in organsize control and tumorigenesis: an updated version [J]. Gene.Dev,2010,24(9):862-874.
  • 5Tu K,Yang W, Li C, et al. Fbxw7 is an independent prognosticmarker and induces apoptosis and growth arrest by regulatingYAP abundance in hepatocellular carcinoma [ J ]. MolecularCancer, 2014, 13:110. PMID:24884509.
  • 6Jiao S,Wang H,Shi Z, et al. A peptide mimicking VGLL4function acts as a YAP antagonist therapy against gastric cancer[J]. Cancer Cell,2014 ,25(2) : 166-180.
  • 7Wang L, Shi S, Guo Z, et al. Overexpression of YAP and TAZis an independent predictor of prognosis in colorectal cancer andrelated to the proliferation and metastasis of colon cancer cells[J/OL]. PLoS One,2013,8(6) :e65539.
  • 8Yu FX,Zhao B, Panupinthu N, et al. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling[J]. Cell,2012,150(4):780-791.
  • 9Chen D,Sun Y,Wei Y, et al. LIFR is a breast cancer metasta-sis suppressor upstream of the Hippo-YAP pathway and a prog-nostic marker[J]. Nat Med,2012,18(10) : 1511-1517.
  • 10Hall CA, Wang R, Miao J,et al. Hippo pathway effector Yap isan ovarian cancer oncogene[J]. Cancer Res,2010*70(21) :8517-8525.

共引文献18

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二级引证文献13

实用妇产科杂志
2016年 第6期

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