职业性变态反应性肺泡炎发病机制研究进展

Study progress on pathogenesis of occupational allergic alveolitis

职业性变态反应性肺泡炎是由于生产过程中吸入大量种类复杂的有机粉尘所引起,基本病理改变为肺组织弥漫性炎症和肉芽肿生成。尽管其临床表现的特异性不强,但最终可发展为不可逆的肺组织纤维化,危害不可谓不重。国内外已有不少有关其流行病学规律的报告,并积极探索其发病机制。本文拟从变态反应性肺泡炎的职业暴露、流行病学规律、免疫学发病机制等方面综述相关研究进展,为今后的基础研究提供相关依据。

Occupational allergic alveolitis is induced by inhalating a large variety of organic dust during the production, its basic pathological changes are diffuse inflammation and granuloma formation in lung tissues. Although lacks of clinical feature it can develops to irreversible lung fibrosis at last, the hazard can not be described as not critical. There are not a few study reports on its epidemiological at home and abroad, the research on its mechanism is also actively carried out. This paper will summarize the progresses of the disease especially on its occupational exposure, epidemiological rules and immunological pathogenesis etc., thereby provides some theoretical basis for future studies.