摘要
目的:分析比较耳蜗电图(electrocochleography,ECoch G)中总和电位(summating potential,SP)与动作电位(action potential,AP)的幅度比和面积比两种方法在梅尼埃病(Meniere’s disease,MD)诊断中的应用价值。方法:样本总量为96名成人受试者(共测试123耳)。将其分为3组:对照组由56名听功能正常的受试者组成(共测试76耳),确诊MD组25人(单耳21人,双耳4人,共测试29耳);疑似MD组15人(单耳12人,双耳3人,共18耳)。将对照组的SP/AP幅度比与面积比的95%参考值上限作为阳性参考值,分别计算确诊MD组和可疑MD组的振幅比和面积比阳性率,比较两种方法阳性率的差异性及统计学意义。结果:对照组所得SP/AP幅度比95%参考值范围为:0.01~0.32,以〉0.32为阳性标准;SP/AP面积比95%参考值范围为:0.68~1.82,以〉1.82为阳性标准。确诊MD组中,幅度比的阳性检出率为14.29%(15/105),面积比的阳性检出率为25.71%(27/105),面积比阳性率高于振幅比阳性率(χ^2=6.050,P=0.014)。可疑MD组中,幅度比阳性率为16.67%(3/18);面积比阳性率为77.78%(14/18)。两者阳性率差异有统计学意义(χ^2=9.091,P=0.003),其面积比阳性率高于振幅比阳性率。结论:同SP/AP幅度比相比较,面积比在梅尼埃疾病的诊断中更具有优势。
Objective:To analyze and compare summating potential(SP)and action potential(AP)in electrocochleogram for diagnosing Meniere's disease(MD). Methods:All 96 adults(123 ears)were divided into three groups:control group,MD diagnosed group,MD suspected group. Control group was consisted of 56 subjects with normal function of hearing(76 ears were tested);MD diagnosed group was consisted of 25 subjects(29 ears from 21 subjects with single ear and 4 subjects with double ears);MD suspected group was composed of 15 subjects(18 ears from 12 subjects with single ear and 3 subjects with double ears). The SP/AP amplitude ratio and SP/AP area ratio of MD suspected group and MD diagnosed group were compared. Results:The SP/AP amplitude ratio from 95%reference of control group ranged from 0.01 to 0.32,and the positive standard was higher than 0.32;the SP/AP area ratio from 95%reference was 0. 68-1. 82,and the positive standard was higher than 1.82. In MD diagnosed group,the positive rate of the SP/AP amplitude ratio was 14.29%(15 out of 105);the positive rate of SP/AP area ratio was 25.71%(27 out of 105);the positive ratio of SP/AP area ratio was higher than that of amplitude ratio(χ^2=6.050,P=0.014). In MD suspected group,the positive rate of SP/AP amplitude ratio was 16.67%(3 out of 18)and the positive rate of SP/AP area ratio was 77.78%(14 out of 18). There were statistical differences between SP/AP area ratio and amplitude ratio(χ^2=9.091,P=0.003);the positive ratio of SP/AP area ratio was higher than that of SP/AP amplitude ratio. Conclusion:SP/AP area ratio is superior to SP/AP amplitude ratio in diagnozing MD.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2016年第6期632-636,共5页
Journal of Chongqing Medical University
基金
国家自然科学基金资助项目(编号:81170926)
国家临床重点专科建设项目经费基金资助项目(编号:卫办医政函[2012]649号)
关键词
耳蜗电图
梅尼埃病
总和电位/动作电位
幅度比
面积比
electrocochleography
Meniere's disease
summating potential/action potential
amplitude ratio
area ratio