EV71的感染和抗病毒天然免疫应答

EV71 Infection and Innate Antiviral Innate Immunity

EV71是儿童手足口病的主要病原体,部分感染儿童会出现疱疹性咽峡炎以及严重的肺水肿和/或脑干脑炎。近几年,EV71感染引起的疾病机制研究取得了诸多进展。本文针对目前EV71的敏感细胞、EV71感染激活的信号途径以及EV71感染活化的天然免疫应答或免疫逃逸机制研究进行综述,旨在为EV71抗病毒药物研制和免疫致病机理的研究提供思路。

Enterovirus 71（EV71）is a major agent of hand,foot,and mouth disease in children under five years of age.In some cases,infection with EV71 can result in herpangina,pulmonary edema and/or brainstem encephalitis.In recent years,many advances have been made towards an understanding of EV71 pathogenesis.In this review,we summarize the cell types targeted by EV71,the activation of signaling pathways,the innate antiviral immune response and immune evasion by EV71 to better understand the immunopathogenesis of EV71 and to aid in the development of antiviral drugs.