口腔颌面部尤文肉瘤的影像学和病理学特点（英文）

Image and pathological features of Ewing's sarcoma in the oral and maxillofacial region

目的:系统研究口腔颌面部尤文肉瘤的影像学和病理学特点。方法:将8名患有口腔颌面部尤文肉瘤的患者纳入本研究,并系统评价其X线、CT和MRI图像特征及病理学特点。结果:X线结果显示颌骨尤文肉瘤表现为弥漫性、透射性的囊性结构,边界不清。CT结果显示颌骨肉瘤表现为骨质广泛性破坏并且有溶骨性病变,同时侵犯软组织,但没有骨膜反应。MRI结果显示颌骨尤文肉瘤组织的信号不均匀,边界不清楚同时侵犯相邻的软组织。软组织尤文肉瘤的MRI图像与颌骨尤文肉瘤的MRI表现相似。组织学结果显示尤文肉瘤由小圆细胞组成,并表达CD99、神经元特异性烯醇化酶(NSE)和波形蛋白(Vimentin),不表达Des,CD34,上皮膜抗原(epithelial membrane antigen,EMA)和嗜铬粒蛋白A(chromogranin A,Chg A)等标志物。结论:X线、CT及MRI有助于确定尤文肉瘤的性质、与周围组织的关系及侵犯程度。CD99,NSE和Vimentin免疫组织化学染色有助于尤文肉瘤的病理诊断。

Objective： To systematically evaluate the image and pathological features of Ewing＇s sarcoma （ES） in the oral and maxillofacial region. Methods： Eight patients with ES in the oral and maxillofacial region were enrolled for this study. The X-ray3 computed tomography （CT）, and magnetic resonance imaging （MRI） of ES and the pathological data were systematically evaluated. Results： X-ray image showed a diffuse radiolucency with cystic component and ill-defined borders for bone lesion. CT showed that there was osteolytic mass with extensive bone destruction and soft tissue infiltration, but no periosteal reactions were observed. MRI demonstrated that ES showed an inhomogeneous structure and blurred borders with invasion to adjacent soft tissue for bone lesion. Similar manifestation also showed in MRI images for patients with soft tissues. Histologically） ES composed of small round cells, and expressed CD99, neuron specific enolase （NSE） and vimentin （Vim） in all patients. Desmin （Des）, CD34, epithelial membrane antigen （EMA）, chromogranin A （ChgA）, etc, were negatively expressed in ES cells. Conclusion- X-ray） CT, and MRI are helpful to determine the property, extent and the relationship orES with the surrounding tissues. Immunohistochemical stain of CD99, NSE, and Vim are helpful to confirm the pathological diagnosis orES.