气相色谱法测定血栓心脉宁胶囊中麝香酮含量

Determination of Muscone in Xueshuan Xinmaining Capsules by GC

目的：建立血栓心脉宁胶囊中麝香酮的含量测定方法。方法：采用DB-FFAP色谱柱（30 m ×0.25 mm ×0.2μm）；起始温度为130℃，保持5 min，以2℃· min－1的速率升温至180℃，保持8 min，再以20℃· min－1的速率升温至250℃，保持5 min；氢火焰离子化检测器（ FID），温度250℃。结果：麝香酮进样量在0.01～0.10μg范围内线性关系良好（ r＝0.9997），平均回收率99.31％（ RSD＝0.7％）。结论：本方法简便、准确，重现性好，可以用于血栓心脉宁胶囊的质量控制。

Objective：To establish a GC method for content determination of Muscone in Xueshuan Xinmaining Capsules.Methods：A DB-FFAP column（30 m ×0.25 mm ×0.2 μm） was applied.The initial temperature of oven was set at 130 ℃ for 5 minutes,then raised to 180 ℃for 8 minutes at rate of 2℃per minute , and to 250℃for 5 minutes at rate of 20℃per minute.The detector was FID which was at 250 ℃.Results：The standard curve of Muscone was linear in r the range of 0.01-0.10 μg （ r=0.999 7 ） , the average recovery was 99.31%（ RSD=0.7%）.Conclusion：The method is simple ,accurate and reproducible , which can be used for the qual-ity control of Xueshuan Xinmaining Capsules.