老年痴呆伴有高血压患者抗高血压临床用药疗效及安全性分析

Efficacy and Safety of Antihypertensive Drugs for Treatment of Patients with Senile Dementia Complicated with Hypertension

目的研究老年痴呆伴有高血压患者常用的降压药的临床使用疗效及安全性。方法共收集老年科2011~2014年住院老年人痴呆伴有高血压患者共64例（其中老年性痴呆39例,血管性痴呆15例,混合性痴呆10例）,统计入组患者使用的降压药和抗痴呆用药,服药剂量,合并用药、临床疗效及不良反应。结果老年痴呆伴有高血压患者最主要服用的降压药是钙通道阻滞剂,其中使用氨氯地平（包括左旋氨氯地平）患者占总人数的65.6%。患者服药前后血压明显的降低（P〈0.05）且患者血压得到有效控制,不良反应发生率低。结论钙通道阻滞剂在老年痴呆伴有高血压患者人群使用较为广泛,且具有疗效显著,安全性高的特点。

OBJECTIVE To study on the efficacy and safety of antihypertensive drugs for treatment of patients with senile dementia complicated with hypertension. METHODS Antihypertensive drugs and anti-senile dementia drugs, dosage, drug combination,clinical efficacy and adverse reaction were collected from 64 inpatients with senile dementia complicated with hypertension（ contained 39 Alzheimer’ s disease,15 vascular dementia and 10 mixed dementia） from 2011 to 2014. RESULTS The most commonly used antihypertensive agents were calcium channel blockers in senile dementia patients complicated with hypertension.Amlodipine,including levamlodipine,accounted for 65.6% of the prescriptions. The blood pressure decreased significantly（ P〈 0.05）and was controlled in the normal range with little adverse reaction. CONCLUSION Antihypertensive drugs are widely used in the treatment of patients with senile dementia complicated with hypertension,with the advantages of significant efficacy and safety.