促海马区成体神经发生药物的研究进展

Advance in the study of compounds with potential activities in promotion of adult hippocampal neurogenesis

阿尔兹海默病发病机制尚未阐明,目前临床上使用的药物均只能针对相应症状,不能逆转病情的发展进程,故采用新的治疗策略对阿尔兹海默病进行防治成为必然。海马区为实现学习、记忆和认知调节等功能提供了生理基础,与阿尔兹海默病的发生、发展密切相关。该区域存在成体神经发生现象,在某种意义上实现了大脑的可塑性,有望为阿尔兹海默病等神经退行性疾病的治疗开拓新的领域。本文从促进海马区成体神经发生的角度,提出了阿尔兹海默病的新的治疗方向,并总结了促成体神经发生药物的最新进展。

With the increasing size of aging population all over the world, the incidence of Alzheimer＇sdisease has reached to the highest level in many developed countries. However, the etiology of Alzheimer＇s disease remains largely unknown especially in the biological mechanism. Up to now, it is still a challenge that the disease can＇t be controlled by the approved clinical medicines. As a result, new therapeutic strategies are urgently needed to prevent and cure Alzheimer＇s disease. The hippocampus area is associated with learning, memory, cognitive regulation in the central nervous system, which is closely related to Alzheimer＇s disease. Adult neurogenesis in hippocampal area allows new neuronal cells to emerge in the central nervous system. The brain＇s plasticity is achieved in some sense. This review focuses on the progress in the study of variety of compounds in promotion of neurogenesis in adult hippocampal area in recent years. The potential of these compounds may shed a light on postponing the occurring of Alzheimer＇s disease or even curing it.