静息态fMRI评估酒精注射急性期恒河猴脑功能改变

Acute effects of alcohol on brain function monitored with resting-state fMRI in rhesus monkeys

目的采用静息态fMRI基于分数低频振荡幅度(fALFF)算法评价酒精急性期恒河猴脑功能改变。方法分别对7只雄性健康恒河猴于给予酒精前(对照组)及10min后(酒精组)行静息态fMRI扫描,采用fALFF算法获得两组fALFF值存在差异的脑区。结果静息态下,酒精组fALFF值低于对照组的脑区为右枕叶、右侧颞中回、左侧中央后回、右侧楔叶/距状沟、右侧额上回、后扣带回及小脑、丘脑(P<0.01);酒精组fALFF值高于对照组的脑区包括双侧额上回、双侧颞下回、右侧中央前回、楔前叶、后扣带回、左侧海马、双侧岛叶及脑干、小脑、右侧基底核(P均<0.01)。结论酒精急性期恒河猴脑功能的改变具有全脑效应。

Objective To assess the acute effects alcohol on brain function of healthy rhesus monkeys by resting-state fM- RI-fractional low frequency oscillation amplitude （fALFF）. Methods Seven healthy male rhesus monkeys were studied by resting-state fMRI prior to （control group） and 10 minutes after initiation of alcohol administration （alcohol group）, brain areas with difference of fALFF between two groups were acquired by ALFF algorithm. Results Compared with control group, brain areas with decreased fALFF in alcohol group included the right occipital lobe, right middle temporal gyrus, left posterior central gyrus, right side cuneus/catcarine, right superior frontal gyrus, posterior cingulate and cerebellum, thalamus, and brain areas with increased fALFF included the bilateral frontal gyrus, bilateral inferior temporal gyrus, the right side of the central gyrus, precuneus, posterior cingulate, left hippocampus, bilateral insular cortex and brain stem, cerebellum, right basal ganglia （all P〈0. 01）. Conclusion Acute effects of alcohol on brain function in rhesus monkeys have a global effect.