血浆蛋白质氨甲酰化与慢性肾脏病的相关性研究进展

Research progress on the relationship between plasma protein carbamylation and chronic kidney disease

血浆蛋白质氨甲酰化可导致蛋白质结构及功能变化。氨甲酰化主要由氰酸盐与蛋白质结合产生，慢性肾脏病患者尿素氮水平升高，其分解形成氰酸盐增加，为氨甲酰化的主要来源。血浆蛋白质氨甲酰化可对肾脏产生直接影响，并在慢性肾脏病患者的并发症评估、预后及治疗方面具有潜在价值。本文主要综述血浆蛋白质氨甲酰化及其在慢性肾脏病患者中的价值及治疗前景。

Plasma protein carbamylation may change the structure of protein, thus influencing its function. Carbamylation is mainly through combination of cyanate with protein, which is elevated in patients with chronic kidney disease mainly because cyanate level is raised due to decomposition of the increasing urea in this population. Carbamylated plasma protein may influence the kidney directly, and has potential value in eval- uation of complications, prognosis, and therapy of chronic kidney disease patients. This review introduced plas- ma protein carbamylation and summarized its value as a biomarker in chronic kidney disease, and promising therapy focusing on lowering plasma protein carbamylation based on recent advances.