扶正解毒法改善肺癌分子靶向治疗获得性耐药

Strengthening and Detoxification Method Ameliorating Acquired Resistance of Molecular Targeted Therapy for Lung Cancer

以吉非替尼为代表的分子靶向药物是肺癌领域的里程碑。获得性耐药是制约肺癌分子靶向药物疗效的瓶颈。中医认为:正气亏虚、余毒内蕴是导致获得性耐药的基本病机,扶正解毒是治疗的主要法则。临床与基础研究证明基于扶正解毒治则的中药复方能够改善分子靶向治疗获得性耐药。中医药的优势在于整体调节,与专注于精准治疗的分子靶向药物相结合,有可能发挥宏观与微观的协同效应,成为肺癌治疗的创新模式。

Molecular targeted therapy,such as Gefitinib,is a real milestone in the treatment of lung cancer. The acquired resistance has become the major limitation of molecular targeted therapy for lung cancer. According to the theory of traditional Chinese medicine,the deficiency of vital Qi and cancerous toxin is the major pathogenesis,which causes the acquired resistance of molecular targeted therapy. Strengthening and detoxification method can ameliorate the acquired resistance. Many previous studies have found that herbs for strengthening and detoxification can ameliorate the acquired resistance. Those studies explore the good synergistic effect of traditional Chinese medicine and molecular targeted therapy,providing a new reference to guide the therapy of NSCLC in clinic.