期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Wnt信号通路在纤维化疾病中的研究进展 被引量：4

Progress on Fibrosis Disease via Wnt Signal Pathway
下载PDF
导出
摘要 对近年来Wnt信号通路在纤维化疾病中的研究进展进行综述。Wnt信号分为经典及非经典两种传导途径,其与TGF-β1/Smads通路间存在对话关系。研究证实Wnt通路参与了肺、心、肝、肾等器官的纤维化过程。中医药抗纤维化疾病潜力值得挖掘,以Wnt通路为靶点,可能为阐明中药抗纤维化的机制开拓新的思路。 Wnt pathway plays an important role on fibrosis disease. It has two signal transduction pathways including classical and non- classical ones. There is a cross- talk between Wnt and TGF- β1 / Smads pathways. Chinese medicine has huge therapeutic potential on fibrosis disease. The study of Wnt pathway may help to elucidate the anti- fibrosis mechanism of Chinese medicine.
作者 史俊 盛梅笑
机构地区 南京中医药大学第一临床医学院 南京中医药大学附属医院肾内科 南京中医药大学肾病研究所
出处 《中华中医药学刊》 CAS 北大核心 2016年第7期1637-1640,共4页 Chinese Archives of Traditional Chinese Medicine
基金 国家自然科学基金面上项目(81473606) 江苏省中医药领军人才项目(LJ200904) 江苏省六大人才高峰项目(WS-033) 江苏省高校优势学科建设工程项目(JD11049)
关键词 WNT信号通路 纤维化 中医药 Wnt signal pathway fibrosis Chinese medicine
分类号 R285.5 [医药卫生—中药学]
  • 相关文献

参考文献36

  • 1Wu J,Cohen SM.Repression of Teashirt marks the initiation of wing development[J].Development,2002,129(10):2411-2418.
  • 2Katoh M.WNT signaling pathway and stemcell signaling network[J].Clin Cancer Res,2007,13(14):4042-4045.
  • 3Huelsken J,Behrens J.The Wnt signaling pathway[J].J Cell Sci,2002,15(Pt21):3977-3978.
  • 4Chien AJ,Conrad WH,Moon RT.A Wnt survival guide:from flies to human disease[J].J Invest Dermatol,2009,129(7):1614-1627.
  • 5Valenta T,Hausmann G,Basler K.The many faces and functions ofβ-catenin[J].EMBO J,2012,31(12):2714-2736.
  • 6Cadigan KM,Waterman ML.TCF/LEFs and Wnt signaling in the nucleus[J].Cold Spring Harb Perspect Biol,2012,4:a007906.
  • 7Schmeckpeper J,Verma A,Yin L.Inhibition of Wnt6 by Sfrp2regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways[J].J Mol Cell Cardiol,2015,10(85):215-225.
  • 8Tian X,Zhang J,Tan TK,et al.Association ofβ-catenin with P-Smad3 but not LEF-1 dissociates in vitro profibrotic from anti-inflammatory effects of TGF-β1[J].J Cell Sci,2013,126(Pt 1):67-76.
  • 9Vincent T,Neve EP,Johnson JR,et al.A SNAIL1-Smad3/4transcriptional repressor complex promotes TGF-βmediated epithelial-mesenchymal transition[J].Leukemia,2009,23(5):925-933.
  • 10TULI R,TULI S,NANDI S,et al.Transforming growth factorbeta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk[J].J Biol Chem,2003,278(42):41227-41236.

二级参考文献70

  • 1车颖,徐婷婷,姜妙娜,贾玉杰.肝复康胶囊对实验性肝纤维化大鼠肝细胞的保护作用[J].中药材,2004,27(6):428-429. 被引量：7
  • 2车颖,王善菊,徐婷婷,姜妙娜,贾玉杰.中药肝复康对实验性肝纤维化大鼠肝功能及血清标志物的影响[J].放射免疫学杂志,2004,17(4):283-284. 被引量：5
  • 3曹汐汐,许祖德.Smad与肺纤维化[J].国际病理科学与临床杂志,2006,26(6):488-494. 被引量：5
  • 4Moon RT, Kohn AD, De Ferrari GV, et al. WNT and beta-catenin signalling : diseases and therapies. Nat Rev Genet, 2004,5 : 691-701.
  • 5Tolwinski NS,Wiesehaus E. A nuclear function for armadillo/beta eatenin. PLoS Biol, 2004,2 : E95.
  • 6Chilosi M. Poletti V, Zamo A, et al. Aberrant Wnt/beta catenin pathway activation in idiopathic pulmonary fibrosis. Am J Patbol, 2003,162:1495- 1502.
  • 7Surendran K , Schiavi S, Hruska KA. Wnt dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol, 2005,16 : 2373-2384.
  • 8Castanotto D, Rossi JJ. The promises and pitfalls of RNA interference-based therapeutics. Nature,2009, 457 : 426-433.
  • 9CADIGAN KM,NUSSE R. Wnt signaling: a common theme in animal development[J]. Genes Dev, 1997,11:3286-3305.
  • 10LEE PN,PANG K,MATUS DQ,et al. A WNT of things to come: evolution of Wnt signaling and polarity in cnidarians[J]. Semin Cell Dev Biol,2006,17:157-167.

共引文献134

同被引文献74

引证文献4

二级引证文献5

中华中医药学刊
2016年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部