夜间睡眠时间与女性结直肠癌发病关系的前瞻性队列研究

Sleep duration and the risk of colorectal cancer incidence:a prospective cohort study in the Chinese Kailuan female cohort

目的 研究夜间睡眠时间与女性结直肠癌发病风险关系。方法 自2006年5月开始,以开滦集团全体在职及离退休女性职工为调查对象,建立开滦集团女性动态队列并对其随访。收集研究对象夜间睡眠时间、吸烟等基线信息及结局事件信息。采用多因素Cox比例风险回归模型分析调查对象夜间睡眠时间与结直肠癌发病风险关系。结果 共有24688名研究对象进入队列,共计随访108020.76人年,平均4.38年,共收集结直肠癌新发病例32例。调整年龄等混杂因素后,与夜间睡眠时间7h组相比,睡眠时间≤6h组、≥8h组结直肠癌发病风险的HR（95%CI）值分别为0.41（0.14～1.22）,0.56（0.23～1.40）,差异无统计学意义（P＜0.05）。分别按鼾症、基线BMI水平情况分层后,也未发现夜间睡眠时间长短与结直肠癌发病风险的显著相关性。结论 目前研究结果尚不能肯定夜间睡眠时间长度与中国女性结直肠癌发病风险的显著关联。

Objective To investigate the association between sleep duration and risk of colorectal cancer incidence in women.Methods All the female employees including the female retirees of the Kailuan Group who completed routine physical examinations were recruited in the Chinese Kailuan female cohort.Information on lifestyle such as sleep duration and smoking status was collected at the baseline investigation,as well as the information of newly-diagnosed colorectal cancer cases during the follow-up period.Multivariable Cox proportional hazards regression models were used to evaluate the association between levels of sleep duration and risk of colorectal cancer.Results A total of 24688 females were recruited in the study and there were 108020.76 person-years of follow-up and 4.38 years of average follow-up period.During follow-up,32 colorectal cancer cases were identified in the present cohort.Compared with 7h of sleep duration,the hazard ratio and 95% confidence intervals of colorectal cancer were 0.41（0.14～1.22）and 0.56（0.23～1.40）for short（≤6h）and long（≥8h）sleep duration,respectively,after adjustment for potential confounding factors such as age.Similar results were obtained when analysis was conducted in subgroups stratified by snoring or baseline BMI.Conclusion It is still not sure that sleep duration is significantly associated with risk of colorectal cancer in Chinese female.