广州地区人群癔球症的发病学特征及城乡差异

Epidemiological features of globus in urban and rural communities in Guangzhou

目的 比较广州中心城区和农村社区人群癔球症的发病学特征及其伴发焦虑抑郁状况.方法 以“是否曾发生癔球症症状”为主要调查指标,采用分层整群抽样方法对广州市远景街道和南沙村镇人口中18岁及以上长住居民的癔球症症状（GETS）及焦虑抑郁情绪自评量表进行问卷调查.结果 （1）癔球症终生患病率为21.46％,城区人群患病率（26.48％）显著高于农村人群（16.41％,x2=45.18,P＜0.05）;男女终生患病率差异无统计学意义（P＞0.05）;（2）城市癔球症患者焦虑、抑郁、睡眠障碍的发生率均高于农村癔球症患者（48.80％vs 33.94％,x2=4.35,P＜0.05;40.47％vs25.69％,x2=4.76,P＜0.05; 35.71％ vs 21.10％,x2=5.09,P＜0.05）;（3）癔球症患者GETS与SAS焦虑评分（r=0.234,P=0.002）、SDS抑郁评分（r=0.258,P＜0.05）呈正相关.结论 癔球症在广州人群中并不罕见,常合并其他胃肠道症状,其患病率及伴随的焦虑抑郁状况存在明显的城乡差异.临床试验注册中国临床试验注册中心,ChiCTR-EOC-15006029.

Objective To compare the epidemiological and psychological features of globus in urban and rural communities in Guangzhou.Methods A questionnaire survey was conducted among permanent inhabitants aged 18 years and over in Guangzhou by randomizing cluster sampling under stratification of urban and rural areas.Results The lifetime prevalence of globus was 21.46%.Prevalence of globus was higher in the urban area than in the rural area （26.48% vs 16.41%,x2 =45.18,P〈0.05）.No gender-related difference in prevalence was observed （20.05% vs 22.67%,x2 =3.030,P〉0.05）.The iucidence of anxiety,depression,and sleep disorders was significantly higher in globus respondents in the urban area than in the rural area （48.80% vs33.94%,x2=4.35,P〈0.05;40.47% vs 25.69%,x2 =4.76,P〈0.05; 35.71% vs 21.10%,x-2=5.09,P〈0.05）.Positive correlations were observed between the severity of globus symptoms and SAS （r=0.234,P〈0.05）and SDS（r=0.258,P〈0.05）scores.Conclusion Globus is not rare in Guangzhou and always is combined with other gastrointestinal symptoms.The prevalence and psychological features of globus between urban and rural communities are different.Clinical Trail Registry Chinese Clinical Trail Registry,ChiCTR-EOC-15006029.