艾灸治疗肝郁脾虚证慢性乙型肝炎患者合并慢性疲劳综合征的临床疗效观察

Clinical Study on Effect of Moxibustion Treating Hepatitis B Virus Patients Combine Chronic Fatigue Syndrome

目的:观察艾灸关元、足三里、太冲穴治疗肝郁脾虚证慢性乙型肝炎合并慢性疲劳综合征患者的临床疗效。方法:将98例符合纳入标准的患者分为2组各45例,治疗组采用艾条灸关元、足三里、太冲穴,对照组无艾灸。2组均接受抗病毒药物治疗,4周为1个疗程。采用多维疲劳问卷评估,观察免疫细胞因子IL-6、IL-8、IFN-γ及肝功能ALT、AST、TBil、GGT等实验室指标。结果:2组治疗后的总体疲劳、生理疲劳、精神疲劳、活动减少、兴趣减少积分有降低的趋势,治疗组与对照组各项积分比较差异有统计学意义。治疗组治疗后IL-6、IL-8、水平低于治疗前,而IFN-γ水平高于治疗前,且ALT、AST、TBil、GGT较治疗前改善明显,对肝功能的改善效果优于对照组。结论:艾灸关元、足三里、太冲穴穴治疗肝郁脾虚证慢性乙型肝炎合并慢性疲劳综合征疗效良好。

Objective： To observe the clinical effect of moxibustion treating hepatitis B Virus patients combine chronic fatigue syndrome. Methods： 98 hepatitis B Virus patients combine chronic fatigue syndrome patients were randomized into two groups. The patients in treatment group were treated by moxibustion on Guanyuan,zusanli and taichong one times a day; and control group were no treated by moxibustion. All these patients were followed up 4 weeks to observe the changes in Multidimensional Fatigue Inventory（ MFI-20） and the changes in IL-6、IL-8、IFN-γ ALT、AST、TBil、GGT. Results：There are decreasing trend in both groups MFI index,and there was significant difference between two groups in MFI index. There are significant difference between two groups in IL-6、IL-8、IFN-γ、ALT、AST、TBil、GGT. Conclusion：Moxibustion on Guanyuan,zusanli and taichong can significantly ameliorate in treating hepatitis B Virus patients combine chronic fatigue syndrome.