质子泵抑制剂长期应用的安全性研究进展

Research progress on application safety of long term proton pump inhibitor

质子泵抑制剂是治疗酸相关性疾病的首选药物,由于其显著的疗效和良好的安全性,临床应用越来越广泛,处方量与日俱增。但近几年来,质子泵抑制剂长期应用导致的潜在不良反应(如营养素缺乏、骨质疏松症、呼吸道和肠道感染、胃底腺息肉等)备受关注,也颇具争议。本文就质子泵抑制剂长期应用的安全性研究进展做一综述。

Proton pump inhibitors （PPI） are the first choice for the treatment of acid related diseases. As they are efficient and safe, they are increasingly applied in clinical applications and prescriptions of growing. But in recent years, the potential adverse reactions caused by long-term application of PPI （such as lack of nutrients, osteoporosis, respiratory and intestinal infection, fundic gland polyps, etc.） have attracted much attentions with controversies. This review is written about the safety of the long-term application of PPI.