复方苦参注射液腹腔灌注治疗胃癌晚期腹腔积液疗效观察

The effect of compound sophora injection in the treatment of advanced gastric cancer patients with peritoneal effusion

目的：探讨复方苦参注射液腹腔灌注治疗胃癌晚期腹腔恶性积液的疗效。方法选择60例胃癌晚期腹腔积液患者根据治疗方法不同分为 A 组31例和 B 组29例，A 组予复方苦参注射液腹腔灌注治疗，每周治疗2次，共4周；B 组予复方苦参注射液静脉滴注，每天1次，连续4周。比较两组疗效。结果A组有效率为58．1％，优于 B 组的27．6％，差异有统计学意义（χ2＝5．69，P ＜0.05）。结论复方苦参注射液腹腔灌注治疗胃癌晚期腹腔恶性积液可以提高疗效，并且不良反应轻，值得临床推广。

Objective To investigate the effect of intraperitoneal injection of compound sophora injection in the treatment of advanced gastric cancer patients with malignant peritoneal effusion.Methods 60 advanced gastric cancer patients with peritoneal fluid were randomly divided into two groups according to the different treatment meth-ods.A group of compound sophora injection with intraperitoneal therapy（group A）,treatment 2 times per week for four weeks,Another group of compound sophora injection with vein therapy （group B）,for 4 consecutive weeks.The efficacy of the two groups was compared.Results The effective rate of group A was 58.1%,which was higher than 27.6% of group B,the difference was statistically significant（χ2 =5.69,P 〈0.05）.Conclusion Intraperitoneal perfusion with compound sophora injection can improve the effect in the treatment of peritoneal effusion in patients with advanced gastric cancer,and the adverse reaction is mild,it is worthy of clinical application.