奥美拉唑联合抗生素治疗胃溃疡的疗效及不良反应观察

Observation Curative and Untoward Effect on Omeprazole Combined With Antibiotics in Treatment of Gastric Ulcer

目的观察奥美拉唑联合抗生素治疗胃溃疡的疗效及不良反应。方法将我院收治的52例胃溃疡患者作为研究对象,随机分组,各26例。西咪替丁组予以甲硝唑片、阿莫西林及西咪替丁片治疗,奥美拉唑组予以甲硝唑片、阿莫西林及奥美拉唑肠溶片治疗。对比两组患者临床效果、不良反应发生率。结果西咪替丁组临床总有效率69.2%,低于奥美拉唑组96.2%,差异有统计学意义(P<0.05);西咪替丁组不良反应发生率46.2%,高于奥美拉唑组15.4%,差异有统计学意义(P<0.05)。结论应用抗生素与奥美拉唑联合治疗胃溃疡可提高其临床效果,有效降低不良反应发生率。

Objective To observe the curative effect and adverse reaction of omeprazole combined with antibiotics in the treatment of gastric ulcer.Methods 52 cases of gastric ulcer patients treated in our hospital were studied, random divided into difference groups, each of 26 cases. The cimetidine group were given metronidazole tablets, amoxicillin and cimetidine tablets treatment, The omeprazole group received metronidazole tablets, amoxicillin and omeprazole enteric-coated tablets treatment. The clinical effect and incidence of adverse reactions in the two groups were analyzed. Results The clinical total effective rate of cimetidine group was 69.2%, lower than the omeprazole group 96.2%, and the difference was significant（P〈0.05）, The incidence of adverse reactions in cimetidine group was 46.2%, higher than that in omeprazole group 15.4%, the difference was significant（P〈0.05）. Conclusion The combination of antibiotics and omeprazole in the treatment of gastric ulcer can significantly improve the clinical effect, reduce the incidence of adverse reactions.