强化瑞舒伐他汀治疗冠脉慢血流患者的疗效及对颈动脉内膜厚度的影响

Influence of intensive rosuvastatin on the efficacy and carotid intimal thickness of patients with coronary slow flow

目的探讨强化瑞舒伐他汀治疗冠脉慢血流(CSF)患者的疗效及对颈动脉内膜厚度的影响。方法将30例CSF患者随机分为两组(各15例),分别接受每日10 mg(A组)或20 mg(B组)瑞舒伐他汀治疗,疗程6个月,分析两组的治疗效果,记录心绞痛发作次数、持续时间,比较两组治疗前后的冠状动脉血流速度及颈动脉内膜厚度。结果两组的总有效率为100.0%,B组的显效率为73.3%,高于A组的53.3%(P<0.05);B组治疗后的心绞痛症状、冠状动脉血流速度及颈动脉内膜厚度均优于A组(P<0.05)。结论强化瑞舒伐他汀治疗CSF患者的效果较好,可有效改善心绞痛、冠状动脉血流速度及颈动脉内膜厚度。

Objective To explore the influence of intensive rosuvastatin on the efficacy and carotid intimal thickness of patients with coronary slow flow（ CSF）. Methods 30 patients with CSF were randomly assigned to receive 10 mg/d（ n = 15,A group） or 20 mg/d（ n = 15,B group） rosuvastatin for six months. The therapeutic effect of two groups was recorded. The incidence and duration of angina,coronary artery blood flow velocity and carotid intimal thickness were compared before and after treatment in both groups. Results The total effective rate was 100% in both groups,while obvious efficiency rate of B group was 73. 3%,higher than 53. 3%in A group（ P〈0.05）. Compared with A group,there were less incidence and duration of angina,higher coronary artery blood flow velocity and lower intimal thickness of carotid artery in B group（ P〈0.05）.Conclusions There is a better efficacy of intensive rosuvastatin on CSF patients,it can improve angina,coronary flow velocity and carotid intimal thickness.