脂蛋白相关磷脂酶A2与急性脑梗死相关性研究

Association Study on Lipoprotein Associatedn Phospholipase A2 and Acute Cerebral Infarction

目的:探讨血清脂蛋白相关磷脂酶(Lp-PL)A2水平与急性脑梗死(ACI)的相关性。方法:分析ACI(100例)和对照(51例)组间临床资料的差异;二分类Logistic回归分析ACI的相关危险因素。结果:与对照组比,ACI组高血压病史、糖尿病史、吸烟、颈动脉斑块、颈动脉内中膜厚度(IMT)、血清Lp-PLA2、总胆固醇、甘油三酯(TG)、高、低密度脂蛋白胆固醇、同型半胱氨酸(HCY)、胱抑素、尿酸、C反应蛋白、总胆红素有统计学意义(P<0.05)。Logistic回归分析结果示血清Lp-PLA2、TG、HCY、颈动脉斑块是ACI的危险因素(OR>1,P<0.05)。而血清Lp-PLA2的ROC曲线下面积提示其对ACI有预测价值。结论:高血清Lp-PLA2水平是脑梗死的独立危险因素,其对ACI有一定预测价值。

Objective： To investigate the relationship between lipoprotein associated phospholipase （Lp-PL） A2 and acute cerebral infarction （ACI）. Methods： The difference of clinical data between ACI （100 cases）and control （51 cases）groups was analyzed. The related risk factors of ACI were determined by Logistic regression analysis. Results： Compared with control group, there were statistical difference in hypertension, diabetes, smoking, carotid artery plaque, carotid intima-media thickness, serum Lp-PLA2, total cholesterol, triglyceride （TG）, high density lipoprotein cholesterol, low densitylipoprotein cholesterol, homocysteine （HCY）, cystatin, uric acid, C reactive protein and total bilirubin in the ACI group. The serum Lp-PLA2, TG, HCY and carotid artery plaque were risk factors of ACI by Logistic analysis （OR〉l, P〈0.05）. ROC curve of serum Lp-PLA2 showed predictive values to ACI. Conclusion： High serum Lp-PLA2 level is an independent risk factor for cerebral infarction and shows the predictive value to ACI.