百令胶囊辅助治疗对紫癜性肾炎患儿尿MCP-1、mAlb及24h尿蛋白定量的影响

Effect of Bailing Capsules Adjuvant Treatment on the Quantification of Urinary MCP-1,mAlb and 24h Urinary Protein in Pediatric Patients with Henoch-schonlein Purpura Nephritis

目的：探讨百令胶囊辅助治疗对过敏性紫癜性肾炎（HSPN）患儿尿单核细胞趋化蛋白-1（MCP-1）、尿微量蛋白（m Alb）及24h尿蛋白定量（Up）水平的影响。方法：64例HSPN患儿随机分为普通组与百令组各32例。普通组给予常规激素、潘生丁、氯雷他定等治疗,百令组在此基础上加用百令胶囊0.4~0.6 g,po,tid。疗程均为4周。观察两组患儿治疗前后尿MCP-1、m Alb及24h Up水平的变化。结果：治疗4周后,两组患儿尿MCP-1、m Alb及24h Up均较治疗前下降（P〈0.05）,且百令组较普通组下降更显著（P〈0.05）。结论：百令胶囊辅助治疗HSPN,能显著减少蛋白尿,改善肾功能。

Objective：To observe the effect of Bailing capsules adjuvant therapy on urinary monocyte chemoattractant protein-1（ MCP-1）, microalbuminuria（mAlb） and 24h urinary protein（Up）in the children with henoch-schonlein purpura nephritis（HSPN）. Methods：Totally 64 cases of HSPN children were randomly divided into two groups with 32 cases in each .The normal group was given the conventional hormone , dipyridamole and loratadine etc .The Bailing group was orally treated with Bailing capsules additionally .The therapy course was 4 weeks, the changes of MCP-1,mAlb and 24hUp in the groups before and after the treatment were observed .Re-sults：Before the treatment, the levels of MCP-1,mAlb and 24hUp were similar between the groups （P〉0.05）.After the 4-week treatment, the levels of MCP-1,mAlb and 24hUp were lower than those before the treatment （P〈0.05）,and the decrease in Bailing group was more significant than that in the normal group （P〈0.05）.Conclusion：Bailing capsules adjuvant treatment for HSPN can significantly reduce albuminuria and improve renal function .