氯雷他定与无极膏治疗小儿外耳湿疹疗效观察

Clinical Efficacy and Safety Evaluation of Loratadine Combined with Compositus Mentholi Cream in the Treatment of Infantile with External Ear Eczema

目的:探讨氯雷他定与无极膏治疗小儿外耳湿疹临床疗效及其安全性。方法:小儿外耳湿疹96例随机分为观察组48例与对照组48例。两组患儿均采用常规处理,对照组采用无极膏外用治疗,观察组在对照组基础上加用氯雷他定片治疗。两组疗程均为10d。比较两组患儿的治疗疗效,治疗前后血清白细胞介素-4(IL-4)、干扰素-γ(IFN-γ)、免疫球蛋白-E(Ig E)水平变化,用药期间药品不良反应发生情况及随访6个月复发情况。结果:观察组总有效率(95.83%)高于对照组(79.17%,P<0.05)。两组患儿血清IL-4、IFN-γ、Ig E水平治疗后均有明显下降(P<0.05),且观察组患儿血清IL-4、IFN-γ、Ig E水平明显低于对照组(P<0.05)。两组药品不良反应发生率差异无统计学意义(P>0.05);观察组患儿复发率(8.33%)低于对照组(22.92%,P<0.05)。结论:氯雷他定与无极膏治疗小儿外耳湿疹临床疗效显著,安全可靠。

Objective：To investigate the clinical efficacy of loratadine combined with compositus mentholi cream in the treatment of infantile with external ear eczema and evaluate the safety .Methods：Totally 96 cases of infantile with external ear eczema were ran-domly divided into the observation group （n=48） and the control group （n=48） according to a random number table .Both groups were given the conventional treatment .The control group was treated with topical compositus mentholi cream , while the observation group was treated with loratadine additionally .Both groups were treated for 10 d.The clinical efficacy , the level changes of interleukin-4 （IL-4）, interferon-γ（IFN-γ） and immunoglobulin-E （IgE） before and after the treatment, the incidence of adverse reactions during the treatment and the relapse after 6-month follow-up were compared between the groups .Results：The total effective rate of the obser-vation group （95.83%） was significantly higher than that of the control group （79.17%, P〈0.05）; the levels of IL-4, IFN-γand IgE in both groups were significantly decreased after the treatment （P〈0.05）, and those in the observation group were significantly lower than those in the control group （P〈0.05）;there was no significant difference in the incidence of adverse reactions between the groups （P〈0.05）; the recurrence rate in the observation group （8.33%） was significantly lower than that in the control group （22.92%, P〈0.05）.Conclusion：The clinical efficacy of loratadine combined with compositus mentholi cream in the treatment of infantile with external ear eczema is reliable with promising safety .