黄酮类化合物抗炎作用机制研究进展

Advance in Studies on Anti-inflammatory Mechanism of Flavonoids

黄酮类化合物是植物的次级代谢产物之一,广泛存在于多种植物中。其药理作用广泛,具有抗炎、抗肿瘤、抗菌及病毒、清除自由基、防止骨质疏松、保护心血管的作用。本文通过查阅近年来国内外发表的相关文献,从炎症产生的的重要通路,如花生四烯酸代谢途径、细胞因子及其受体、活性氧、NO途径、核因子、细胞间黏附分子等来对黄酮类化合物的抗炎作用机制进行综述,以期为黄酮类化合物进一步开发提供理论基础和研究方向。

Flavonoids are the secondary metabolites of plants , which are found in many plants .Flavonoids have extensive phar-macological actions , such as anti-inflammation, anti-tumor, anti-bacteria and anti-virus, scavenging free radicals , osteoporosis preven-tion and cardiovascular protection .Based on the analysis of relative literatures published at home and abroad in recent years , the mech-anisms of anti-inflammatory effects of flavonoids were reviewed , including arachidonic acid metabolism pathway , cytokine and its recep-tor, cell second messenger, active oxygen, nitrogen monoxide, platelet activating factor and its receptor , nuclear factor, intercellular adhesion molecule and so on .The review aimed to provide theoretical basis for the further development and research .