摘要
目的:对好康舒胶囊进行添加降糖类化学药物进行检测。方法:采用超高效液相色谱-串联质谱(UPLC-MS/MS)法,ACQUITY BEH C18柱(50 mm×2.1 mm,1.7μm);以甲醇和0.01 mol·L-1的乙酸铵溶液进行梯度洗脱。通过分子离子峰、二级质谱的碎片离子信息及多反应监测(MRM)模式下色谱峰的保留时间等信息,对本品中是否含盐酸二甲双胍等11种化学降糖药物的检出情况进行判定。结果:对11种化学降糖药物检测分析,好康舒胶囊中检出盐酸苯乙双胍及格列苯脲二种化学降糖药物。结论:好康舒胶囊中非法添加了盐酸苯乙双胍和格列苯脲化学降糖药物。
Objective：To detect the hypoglycemic drugs illegally added in Haokangshu capsules .Methods： High performance liquid chromatography-tandem mass spectrometry （UPLC-MS/MS） was used with an ACQUITY BEH C18 column（50 mm ＆#215;2.1 mm, 1.7 μm）and methanol-0.01 mol＆#183; L-1 ammonium acetate as the mobile phase with gradient elution .Through the molecular ion peak, the second order mass fragment ion information and MRM mode chromatographic peak retention time and the other information , the cap-sules containing metformin hydrochloride and 11 kinds of chemical hypoglycemic drugs were determined .Results：Through the analysis of 11 chemical hypoglycemic drugs , two chemical hypoglycemic agents , phenformin and glyburide , were detected out in the capsules . Conclusion：Phenformin and glibenclamide are illegally added in Haokangshu capsules .
出处
《中国药师》
CAS
2016年第7期1387-1391,共5页
China Pharmacist
