微波消解ICP-MS法测定复方丹参片中5种金属元素含量

Determination of Five Heavy Metals in Fufang Danshen Tablets by Inductively Coupled Plasma Mass Spectrometry with Microwave Digestion

目的:建立电感耦合等离子体质谱法(ICP-MS)测定复方丹参片中铅、砷、铜、镉、汞的含量。方法:微波消解后的样品,加入锗、铟、铋内标元素,以菠菜作为质控标准物质,采用电感耦合等离子体质谱法测定复方丹参片中铅、砷、铜、镉、汞的含量。结果:铅、砷、铜、镉、汞5种元素的最低检出限分别为6.5,2.3,5.9,4.7,0.91 ng·g-1;在各自的浓度范围内线性关系良好(r均>0.998 0);回收率分别为102.8%,105.1%,104.5%,106.8%,92.4%,RSD分别为2.1%,2.8%,1.9%,2.2%,3.4%(n=9)。结论:本方法准确迅速,操作性强,干扰少,适用于测定复方丹参片中重金属的含量。

Objective：To establish a quantitative determination method for Pb , As, Cu, Cd and Hg in Fufang Danshen tablets by inductively coupled plasma mass spectrometry （ ICP-MS） with microwave digestion .Methods： The samples were digested by micro-wave and calibrated by the internal standard elements （ In, Ge and Bi ） , and with spinach as the controlled reference standard , the contents of Pb, As, Cu, Cd and Hg were analyzed.Results：The minimum detection limit of Pb, As, Cu, Cd and Hg was 6.5,2.3, 5.9,4.7 and 0.91 ng.g-1, respectively, a good linear relationship was obtained respectively within the concentration range （r〉0.998 0） with the average recovery of 102.8%,105.1%,104.5%,106.8%and 92.4%and RSD of 2.1%,2.8%,1.9%,2.2%and 3.4%（n=9）, respectively.Conclusion：The method is accurate and fast with little interference , and suitable for the determination of heavy metal elements in Fufang Danshen tablets .