辅助生殖技术子代生长发育状况分析

Growth and development status of offspring achieved by assisted Reproductive technology

目的探讨研究辅助生殖技术(assisted reproductive technology,ART)对子代生长发育状况的影响,为下一步ART技术更好的临床应用提供理论指导。方法收集2009年1月至2013年12月31日在本院生殖中心行辅助生殖技术治疗并成功受孕分娩的孕妇子代为实验组,随机抽取同期自然受孕出生的子代为对照组,采用完全随机设计对可能影响两组研究结果的婚姻状况、家庭年收入、父母亲文化程度等外在因素进行配对以消除这些因素对结果的干扰,通过病例查阅进行回顾性总结分析和随访及现场召回调查研究的方法,比较两组儿童的围产期结局和远期体格及神经精神发育状况之间的差异性,研究ART技术对子代生长发育状况的影响,为下一步ART技术更好的临床应用提供理论指导。结果 ART组子代在围产期剖宫产率、双胎妊娠率、早产儿率、低出生体重儿率均高于自然受孕组子代;而在远期体格发育及神经精神发育评价上,两组差别无统计学意义。结论辅助生殖技术所产生子代与自然受孕所产生的子代远期体格及神经发育状况无明显差别。

Objective：To investigate the growth and neurodevelopmental outcome of offspring achieved by Assisted reproductive technology（ART）,and provide theoretical guidance for further clinical applications of ARTs. Methods：Offspring achieved by ART in our reproductive center were recruited between January 2009 and December 2013 as experimental group. Meanwhile,natural born offspring were randomly selected the same period as control group. Eliminate potential interference from marital status,family income,parents education and so on external factors with completely randomized design. In order to compare perinatal outcomes and the long-term physical and neurological development of the two groups,clinical cases were retrospective analysed while relevant offspring were recalled for investigation. To investigate the growth and neurodevelopmenta1 outcome of offspring born by ART,and provide theoretical guidance for further clinical applications of ART. Results：The ART group offspring in cesarean delivery rate,gemellary pregnancy rate,premature rate and low birth weight rate were higher than that of group natural born children;however,there were no statistically difference between the two groups in long-term physical and neurological development.Conclusion：There were no statistically difference in long-term physical and neurological development between assisted reproductive technology conceived offspring and natural born children.