陕西汉族PCI术后人群CYP2C19基因多态性分析

Genetic polymorphism analysis of CYP2C19 in Shaanxi Han population after percutaneous coronary intervention

目的描述陕西省汉族PCI术后人群的细胞色素2C19(CYP2C19)基因型分布特征。方法采用个体化基因诊断芯片技术对1 220例陕西汉族PCI术后人群进行CYP2C19基因分型检测。结果陕西汉族术后人群中男性野生基因型比例为34.02%(*1*1),突变杂合子基因型比例为33.61%(*1*2和1*3),突变纯合子基因型比例为9.43%(*2*2、*2*3和*3*3)。女性野生基因型比例为9.34%(*1*1),突变杂合子基因型比例为11.23%(*1*2和1*3),突变纯合子基因型比例为2.38%(*2*2、*2*3和*3*3)。结论陕西汉族PCI术后人群CYP2C19基因多态性以野生型纯合子*1*1和突变杂合子*1*2为主。

AIM To study the characteristics of CYF2C19 genotype in Shaanxi Han population after percu- taneous coronary intervention （PCI） and establish a foundation for individualized treatment. METHODS Genotyping of CYP2C19 in 1 220 Shaanxi Han patients after PCI were determined by gene chip. RESULTS According to genotyping results, the frequencies of wild type （WT） ＊ 1 ＊ 1 in Shaanxi Han population were 34.02%, WT ＇1＂2 and ＂1＂3 were 33.61%, and WT ＊2＊2, ＊2＊3 and ＊3 ＊3 were 9.43% in males. The frequencies of WT ＊ 1 ＊ 1 were 9.34% , WT ＊ 1 ＊2 and ＊ 1 ＊3 were 11.23% , and WT＊ 2 ＊ 2, ＊ 2 ＊ 3 and ＊ 3 ＊ 3 were 2.38% in females. CONCLUSION Genetic polymorphism analysis of CYP2C19 WT ＊ 1 ＊ 1 and ＊ 1 ＊ 2 in Shaanxi Han population after PCI are most frequent.