高尿酸血症与代谢综合征及其组分的相关性

Correlation of hyperuricemia and metabolic syndrome components

目的分析高尿酸血症与代谢综合征及其组分的相关性。方法选择2014年新疆医科大学第一附属医院体检中心符合入选标准的2 778名体检者,根据高尿酸血症的诊断标准分为高尿酸血症组(593例)及正常尿酸组(2 185例),对收集的临床及生化指标进行统计分析。结果高尿酸血症相关因素的单因素分析显示,性别、体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)及是否并发代谢综合征(MS)在高尿酸血症组与正常尿酸组间分布差异有统计学意义(P<0.01);经多因素Logistic回归分析,BMI(超重/肥胖)、高血压病(SBP、DBP)、高TG、低HDL-C及MS是高尿酸血症发生的相关因素(P<0.01);Pearson相关性分析示高尿酸血症与HDL-C呈负相关(r=-0.195,P<0.001)。结论高尿酸血症与代谢综合征组分密切相关。

AIM To analyze the correlation of hyperuricemia （HUA） and metabolic syndrome （MetS） components. METHODS A total of 2778 subjects who underwent physical examination in the First Affiliated Hospital of Xinjiang Medical University in 2014 were divided into HUA group （593 cases） and normal uricemia group （2185 cases） according to the diagnostic criteria of hyperuricemia. Clinical data and biochemical indices were collected and statistical analysis was conducted. RESULTS Univariate analysis of hyperuricemia showed that the distribution of gender, body mass index （BMI）, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, triglyceride （TG）, high-density lipoprotein （HDL-C）, fasting plasma glucose （FPG） and MetS in HUA group was significantly different from that in normal uricemia group （P 〈 0. 01 ）. Logistic regression indicated that overweight/obesity, hypertension, higher levels of TG, lower level of HDL-C and MetS were factors correlative of HUA （P 〈0. 01 ）. CONCLUSION Hyperuricemia is closely related to components of MetS. Pearson correlation suggests that hyperuricemia was negatively correlated with high-density lipoprotein （HDL-C） （r = - 0. 195. P 〈 0.01 ）.