新疆焉耆县维吾尔族血尿酸水平与高血压水平和动脉硬化严重程度的相关性

Correlation between serum uric acid levels and arterial stiffness in Uygur hypertensive patients

目的通过回顾性分析新疆焉耆县维吾尔族高血压病患者血尿酸（SUA）水平与高血压水平及SUA水平与臂踝脉搏波传导速度（baPWV）和颈动脉内膜中层厚度（ITM）的相关性。方法 选取2014～2015年在新疆焉耆县人民医院住院的206例高血压病患者，根据SUA水平分为2组：高SUA血症组患者149例，并在该组中根据SUA的二分位数值，将以SUA 466 μmol/L为界限分为两亚组SUA水平〈466 μmol/L的A组61例，以及SUA水平≥466 μmol/L的B组88例。并将SUA水平正常者列为对照组共57例。所有患者均于入院时应用同一台全自动动脉硬化测定仪测量baPWV，并由同一名血管超声技师应用同一台超声探头行ITM检测。结果两组间血压水平对照组与试验组比较，试验组中两亚组比较均有统计学意义（P〈0.05）。两组间baPWV和ITM比较，试验组中两亚组比较P〈0.05。而相关性分析提示试验组中两亚组血压比较P〈0.05，且血压水平与SUA水平相关性分析有相关性，SUA水平与血压水平呈正相关。结论SUA水平对预测高血压及动脉硬化有重要的意义，且SUA水平越高，其颈动脉的粥样斑块越严重，两者有非常显著的相关性。

AIM To analyze the correlation between serum uric acid （SUA） level, blood pressure, blood uric acid level, braehial-ankle pulse wave velocity （baPWV） and carotid artery intima-media thickness （IMT） in Uygur hypertensive patients in Yanqi County of Xinjiang. METHODS A retrospec- tive analysis was conducted in 206 hospitalized hypertensive patients from 2014 -2015 in Yanqi County People＇s Hospital. According to the level of blood uric acid, patients were divided into hyperuricemia group （ experimental group, n = 149） and normal SUA group （ control group, n = 57 ）. The experimental group was subdivided into group A （ n = 61 ） with SUA level 〈 466 μmol/L and group B （ n = 88 ） with SUA value ≥466 μmol/L, baPWV of all patients was measured with the same automatic detector and IMT was probed by the same technician. RESULTS Statistically significant difference was found in blood pressure levels, IMT and baPWV between the experimental group and control group and between the two subgroups in the experimental group （all P 〈 0.05 ）. Correlation analysis showed that blood pressure levels were positively correlated with SUA levels. CONCLUSION SUA levels are of significance for predicting hypertension and arterial atherosclerosis. Blood pressure levels are positively correlated with SUA levels the higher uric acid levels, the more serious atherosclerotic plaques of the carotid artery.