丹红注射液对心肺复苏患者早期凝血功能的影响

Protective effects of danhong injection on early coagulation after cardiopulmonary resuscitation

目的探讨丹红注射液对心肺复苏(CPR)患者早期凝血功能的影响。方法 72例CPR患者随机分为试药组(n=37)、复苏组(n=35),试药组再灌注后在常规复苏基础上予丹红注射液,观察2组凝血功能指标及APACHEⅡ评分的变化。结果试药组治疗后活化部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)、血浆凝血酶时间(TT)、纤维蛋白原(FIB)、血小板平均体积(MPV)、APACHEⅡ评分与较试药组治疗前及与复苏组治疗后比较降低(P<0.05),血小板计数(PLT)增高(P<0.05)。结论丹红注射液能有效减少心肺复苏再灌注凝血异常的发生,改善预后。

AIM To investigate the protective effects of danhong injection on coagulation after cardiopul- monary resuscitation （CPR）. METHODS After cardiopulmonary resuscitation, 72 patients were randomly divided into danhong injection treatment group （n = 37 ） and resuscitation group （n = 35 ）, and 30 healthy subjects served as control group. Routine treatment was adopted for all patients. In the treat- ment group, danhong injection was added in addition to the routine treatment. Coagulation was examined in all three groups and APACHE Ⅱ scores were evaluated in the treatment group and resuscitation group. RESULTS Coagulopathy was demonstrated in both treatment group and resuscitation group. After treat- ment, prothrombin time （PT）, thrombin time （TF）, fibrin （FIB）, mean platelet volume （MPV） and APACHE II score were all significantly lower, and platelet （PLT） count was higher in treatment group compared with PLT count in treatment group before treatment and those in resuscitation group after treat- ment （P 〈 0. 05 ）. CONCLUSION Danhong injection can effectively reduce coagulopathy and improve clinical outcomes.