摘要
液滴微流控芯片技术最主要的特点是能够产生单分散的液滴,可作为微反应器,具有高通量、反应迅速、试剂消耗少、操作灵活、自动化和集成化等优点。近年来该技术逐渐应用于药物的高通量筛选和细胞水平的筛选,并显示出良好的应用前景。本文对液滴微流控芯片中液滴的生成和操控技术的研究进展,及其在药物筛选中的应用作一综述。
The main characteristic of the droplet-based microfluidic chip is that it can produce monodisperse droplets, which can be used as a microreactor. It has the advantages of high throughput,rapid reaction,less reagent consumption, flexible operation,automation and integration. The technique has been recently applied in high-throughput drug screening and single cell screening,and proved to be a promising method. This article reviews the current technologies of droplet generation and manipulation in the microfluidic chip,as well as the applications of the chip in drug screening.
出处
《药学服务与研究》
CAS
2016年第3期163-169,共7页
Pharmaceutical Care and Research
基金
国家自然科学基金(81373376)
关键词
液滴微流控
药物筛选
生成
操控
综述
droplet-based microfluidic chip
drug screening
generation
manipulation
review
