药学服务干预对社区多药控制2型糖尿病病人的影响

Influence of pharmaceutical care intervention on type 2 diabetes patients with multi-drug therapy in the community

目的:研究药学服务干预对社区接受多药控制的2型糖尿病病人的影响。方法:通过随机对照研究药师主导的药学服务效果,比较干预组、对照组病人的用药依从性、血糖指标、药品不良反应(ADRs)发生率、满意度等的差异。结果:经1年研究,干预组的用药依从性由31.5%提高到90.4%,对照组的用药依从性由36.0%提高到61.3%,有显著性差异(P<0.05);糖化血红蛋白(HbA1c)达标率干预组由30.1%提高到52.1%,对照组仍为45.3%;ADRs发生率干预组由41.1%下降到4.1%,对照组由41.3%下降到38.7%;干预组病人的满意度得分明显高于对照组,差异有统计学意义(P<0.001)。结论:药学服务干预可提高社区接受多药治疗的2型糖尿病病人的用药依从性、HbA1c控制率、满意度,降低ADRs发生率。

Objective： To study the influence of pharmaceutical care intervention on type 2 diabetic patients with multi-drug therapy in the community. Methods： Through randomized control study with pharmacists playing a leading role, the differences in medication compliance, rates of adverse drug reactions （ADRs）, blood glucose levels, as well as patient satisfaction rates were compared between the patients of the intervention group and the control group. Results： After one year of study, medication compliance of the intervention group increased from 31.5% to 90.40% , while that of the control group increased from 36. 0% to 61.3% , with significant difference （P〈0.05）. Success control rate of glycosylated hemoglobin in the intervention group increased from 30.1% to 52.1%, while that of the control group remained at 45.3%. Rate of ADRs in the intervention group decreased from 41.1% to 4.1% , while that in the control group decreased from 41.3% to 38.7%. Satisfaction rate of intervention group was significantly higher than that of the control group, and statistical significance could be noted, when comparisons were made between them （P〈0. 001）. Conclusion： Pharmaceutical care intervention for type 2 diabetic patients with multi drug therapy in the community could improve medication compliance, success control rate of glycosylated hemoglobin, rate of satisfaction and decrease the rate of ADRs.