穴位注射治疗乳腺癌化疗所致周围神经病变（英文）

Clinical efficacy of acupoint injection for chemotherapy-induced peripheral neuropathy of patients with breast cancer

目的:观察穴位注射治疗乳腺癌化疗所致周围神经病变的临床疗效。方法:采用随机数字表,将符合纳入标准的90例乳腺癌CIPN患者随机分为针刺组、甲钴胺组、穴位注射组,每组30例。针刺组针刺双侧曲池、合谷、足三里、三阴交、血海,甲钴胺组采用甲钴胺注射液1 m L肌肉注射,穴位注射组选穴同针刺组,每穴注入甲钴胺注射液0.1 m L,3组均每3日治疗1次,10次后观察各组临床疗效、神经电生理学及血流变学指标变化。结果:穴位注射组总有效率为93.1%(27/29),高于针刺组78.6%(22/28)及甲钴胺组83.3%(25/30),差异均有统计学意义(均P<0.01);甲钴胺组、穴位注射组能提高病变神经的传导速度(均P<0.01),穴位注射组明显优于其他两组(均P<0.01),针刺组、穴位注射组均能改善血流变学指标(均P<0.05)。结论:穴位注射甲钴胺治疗乳腺癌化疗所致周围神经损伤疗效显著,不仅能提高神经传导速度,还能改善血流变学指标。

Objective To observe the clinical efficacy of acupoint injection for chemotherapy-induced peripheral neuropathy （ClPN）. Methods Ninety ClPN patients with breast cancer conforming to inclusive criteria were randomly divided into an acupuncture group （group A）, a mecobalamin group （group B） and an acupoint injection group （group C） according to random number table, with 30 cases in each group. In group A, acupuncture was conducted at bilateral Q0chi （I~ LI 11）, H6g6 （~ LI 4）, Z0s^nlT （~__~ ST 36）, S^nyinji^o （^-- ~ SP 6） and Xu^h~i （J~ SP 10）; in group B, intramuscular injection with I mL of mecobalamin injection was conducted; and in group C, acupoint selection was the same as group A, and 0.1 mL of mecobalamin injection was injected into each acupoint, respectively. The treatment was conducted once every three days in each group, and the changes of clinical efficacy, nerve electrophysiology and hemorrheology indicators after treatment for 10 times were observed. Result The total effective rate of group C was 93.1% （27/29）, which was higher than 78.6% （22/28） in group A and 83.3% （25/30） in group B, and the differences among three groups were statistically significant （all P〈0.01）; conduction velocity of lesion nerves was improved in group B and group C, the improvement in group C was obviously superior to the other two groups （all P〈0.01）, hemorrheology indicator was improved in group A and group C （both P〈0.05）. Conclusion The efficacy of acupoint injection with mecobalamin for breast cancer CIPN was significant, which can not only improve the nerve conduction velocity, but also improve the hemorrheology indicator.