Effect of three vertigo-stopping needles on neurohumor of patients with cervical vertigo:a controlled trial

止晕三针对颈性眩晕患者神经体液的影响（英文）

Objective To observe the effect of three vertigo-stopping needles on the contents of neuropeptide Y （NPY）, endothelin （ET） and calcitonin gene-related peptide （CGRP） in plasma of patients with cervical vertigo, and to explore its mechanism of treatment. Methods One hundred and eighty patients with cervical vertigo were divided into group A [acupuncture at R6nyfng （人迎ST 9） and Fengchi （风池 GB 20）, and frontal line], group B [acupuncture at Jing jiaji （颈夹脊）, GB 20 and Baihui （百会 GV 20）] and group C [intravenous infusion with ligustrazine and oral administration with flunarizine] according to simple randomization, with 60 cases in each group. For the patients in group A and group B, the treatment was conducted once a day, and ten times were considered as one course of treatment. Two days were free of treatment between two courses, and two courses were needed. For the patients in group C, the treatment was conducted for fifteen days. The contents of NPY, ET and CGRP in plasma before and after treatment were detected in patients with cervical vertigo. Results The contents of NPY in plasma of patients in the three groups after treatment were markedly lower than that before treatment （all P〈0.01）, and the differences were not statistically significant when compared the descending degrees among three groups （P〉0.05）. The contents of ET in plasma of patients in the three groups after treatment were markedly lower than that before treatment （P〈0.05, P〈0.01）, the descending degree in group A was greater than that in group B and group C, and the difference was statistically significant （P〈0.O1, P〈O.05）; while the difference was not statistically significant when compared the descending degrees between group B and group C （P〉0.05）. The contents of CGRP in plasma of patients in the three groups after treatment were markedly higher than that before treatment （P〈0.05, P〈O.O1）, the increasing degree in group A was greater than that in group B and group C, and the difference was statistically significant （both P〈0.05）; while the difference was not statistically significant when compared the increasing degrees between group B and group C （P〉0.05）. Conclusion Three vertigo-stopping needles, acupuncture and medication can regulate the contents of NPY, ET and CGRP in plasma of patients with cervical vertigo, while three vertigo-stopping needles is significantly superior to acupuncture and medication in reducing ET and increasing CGRP.

目的:观察止晕三针对颈性眩晕患者血浆神经肽Y(neuropeptide Y,NPY)、内皮素(endothelin,ET)及降钙素基因相关肽(calcitonin gene-related peptide,CGRP)含量的影响,探讨其治疗机制。方法:将180例颈性眩晕患者按简单随机法分为A组(针刺人迎穴、风池穴、额中线),B组(针刺颈夹脊穴、风池、百会),C组(静滴川芎嗪加口服西比灵)各60例。A、B组治疗每日1次,10次为一疗程,疗程间休息2天,共治疗2个疗程。C组治疗15天。检测颈性眩晕患者治疗前后血浆中NPY、ET、CGRP的含量。结果:3组治疗后血浆中NPY含量较治疗前均有明显下降(均P<0.01),3组之间下降程度比较,差异均无统计学意义(P>0.05)。3组治疗后血浆中ET含量较治疗前均明显下降(P<0.05,P<0.01),A组血浆中ET含量下降程度明显大于B组和C组,差异有统计学意义(P<0.01,P<0.05),而B、C两组之间下降程度比较,差异无统计学意义(P>0.05)。3组治疗后血浆中CGRP含量较治疗前均明显升高(P<0.05,P<0.01),A组血浆中CGRP含量升高程度明显大于B组和C组,差异均有统计学意义(均P<0.05),而B、C两组间升高程度的比较,差异没有统计学意义(P>0.05)。结论:止晕三针、针刺和药物均能有效改善颈性眩晕患者血浆NPY、ET、CGRP的含量,而止晕三针在降低血浆ET含量和升高CGRP含量的作用上明显优于针刺和药物治疗。