A review of inflammatory signaling pathway regulated by acupuncture

针灸调控炎症通路相关研究的回顾（英文）

Objective To analyses the studies about acupuncture regulating inflammatory signaling pathway in treatment of inflammation- related diseases, which can explain the possible mechanism and provide evidence of acupuncture in treatment of inflammatory diseases. Methods Acupuncture-related studies of animal experiments and clinical trials in PubMed about three signaling pathway, Janus protein-tyrosine kinase/signal transducer and activator of transcription （JAK-STAT）, nuclear factor kappa B （NF-KB） and mitogen-act-ivated protein kinase （MAPK） were retrieved. The effective of acupuncture on cytokines of the three signaling pathway were analyzed and systematical（y summarized. Results Acupuncture can inhibit the activity of JAK-STAT, NF-KB and MAPK inflammatory signaling pathway by down-regulate the cytokines of them. Conclusion Acupuncture and moxibustion have the function of anti-inflammation though inhibiting the JAK-STAT, NF-KB and MAPK signaling pathway. Anti-inflammation maybe plays a vital role in the mechanism of acupuncture and moxibustion.

目的:分析近十年来针灸通过调控炎症信号通路治疗炎性疾病的研究,阐述其可能机制,为针灸治疗炎症性疾病提供理论指导。方法:查阅Pub Med上国内外针灸调控酪氨酸激酶-信号转导子和转录激活子(Janus protein-tyrosine kinase/signal transducer and activator of transcription,JAK-STAT),核转录因子kappa B(nuclear factor kappa B,NF-κB)和丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)这三条炎症信号通路治疗炎症性疾病的临床和实验研究,分析其对这三个炎症信号通路中细胞因子的影响,并进行系统归纳。结果:针灸能导致JAK-STAT、NF-κB、MAPK这三条炎症信号通路的上下游细胞因子的表达下降,对这三条通路有明显的抑制作用。结论:针灸能通过抑制炎症信号通路的方式达到抗炎的作用,抗炎作用可能是针灸效应机制的重要组成部分。