期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

盘状结构域受体1在消化系统肿瘤中的表达及其意义

Expression and Significance of Discoidin Domain Receptor 1 in Tumors of Digestive System
下载PDF
导出
摘要 盘状结构域受体1(DDR1)作为一种受体酪氨酸激酶(RTKs)在诸多肿瘤中表达异常,参与肿瘤的生长、浸润、转移等过程,有望成为肿瘤治疗的潜在目标。本文就DDR1在消化系统肿瘤中的表达及其意义作一综述。 Discoidin domain receptor 1 （ DDR1 ） is a kind of receptor tyrosine kinases （ RTKs）, which is expressed abnormally in many tumors. It is involved in the development, invasion and metastasis process of tumors and may become a potential target of tumor therapy. This article reviewed the expression and significance of DDR1 in tumors of digestive system.
作者 杨佳纯 孟燕旎 徐雷鸣
机构地区 上海交通大学医学院附属新华医院消化内科
出处 《胃肠病学》 2016年第6期366-368,共3页 Chinese Journal of Gastroenterology
关键词 盘状结构域受体1 消化系统肿瘤 肿瘤侵袭 肿瘤转移 受体蛋白质酪氨酸激酶类 治疗 Discoidin Domain Receptor 1 Digestive System Neoplasms Neoplasm Invasiveness
分类号 R735 [医药卫生—肿瘤]
  • 相关文献

参考文献29

  • 1Leitinger B. Discoidin domain receptor functions in physiological and pathological conditions [ J ]. Int Rev Cell Mol Biol, 2014, 310: 39-87.
  • 2Valiathan RR, Marco M, Leitinger B, et al. Discoidin domain receptor tyrosine kinases: new players in cancer progression[J~. Cancer Metastasis Rev, 2012, 31 (1-2) : 295-321.
  • 3Leitinger B. Transmembrane collagen receptors [ J ]. Annu Rev Cell Dev Biol, 2011, 27: 265-290.
  • 4Johnson JD, Edman JC, Rutter WJ. A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I -like domain [ J ]. Proc Natl Acad Sci U S A, 1993, 90 (22): 10891.
  • 5Maeyama M, Koga H, Selvendiran K, et al. Switching in discoid domain receptor expressions in SLUG-induced epithelial-mesenchymal transition [ J]. Cancer, 2008, 113 (10) : 2823-2831.
  • 6Carafoli F, Hohenester E. Collagen recognition and transmembrane signalling by discoidin domain receptors [ J ]. Biochim Biophys Acta, 2013, 1834 ( 10 : 2187-2194.
  • 7Playford MP, Butler RJ, Wang XC, et al. The genomlcstructure of discoidin receptor tyrosine kinase [ J ]. Genome Res, 1996, 6 (7): 620-627.
  • 8Alves F, Saupe S, Ledwon M, et al. Identification of two novel, kinase-deficient variants of discoidin domain receptor 1: differential expression in human colon cancer cell lines[J]. FASEB J, 2001, 15 (7): 1321-1323.
  • 9Ongusaha PP, Kim JI, Fang L, et al. p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop[J]. Embo J, 2003, 22 (6): 1289-1301.
  • 10Kim HG, Hwang SY, Aaronson SA, et al. DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notchl activation [ J]. J Biol Chem, 2011, 286 (20) : 17672-17681.

二级参考文献49

  • 1张雅青,顾克东.基质金属蛋白酶与肿瘤关系研究进展[J].西北民族大学学报（自然科学版）,2006,27(3):79-84. 被引量：10
  • 2Vogel W F, Abdulhussein R, Ford C E. Sensing extracellular matrix: An update on discoidin domain receptor function[J]. Cellular Signalling, 2006,15(8 ) : 1108-1116.
  • 3Ram R, Lorente G,Nokolich K, et al. Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2[J]. J Neurooncol,2006,76(3):239-248.
  • 4Hou G, Vogel W, Bendeck M P, et al. The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair[J]. The American Society for Clinical Investigation, 2001,107 ( 6 ):727-735.
  • 5Vogel W F,Abdulhussein R, Ford C E.Sensing extracellular matrix: An update on discoidin domain receptor function[J]. Cellular Signalling, 2006,18(8):1108-1116.
  • 6Alves F,Saupe S,Ledwon M,et al. Identification of two novel, kinase-deficient variants of discoidin domain receptor 1: differential expression in human colon cancer cell lines[J]. FASEB J, 2001,15( 1 ):1321-1323.
  • 7Fang J, Shing Y,Wiederschaim D, et al. Matrix metalloproteinases-2 Is required for the switch to the angiogenic phenotype in a tumor model[J]. ProcNatlA cad, 2000,1997 ( 8 ) : 3884-3889.
  • 8Shenhan KM,Shenhan K,Donoghue DP,et al. The relationshipbetween cyclooxygenase-2 expression and colorectal cancer[j].JAMA,1999,282(13) :1253-1257.
  • 9Alves F, Saupe S, Ledwon M, et al. Identification of two novel,kinase-deficient variants of discoidin domain receptor 1 : differen-tial expression in human colon cancer cell lines [J]. FASEB,2001,15(7):1321-1330.
  • 10Vogel WF,Abdulhussein R, Ford CE. Sensing extracellular ma-trix: An update on discoidin domain receptor function[JJ. Cellu-lar Signalling,2006,18(8) :1108-1116.

共引文献16

胃肠病学
2016年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部