血清胃蛋白酶原、胃泌素-17、幽门螺杆菌抗体检测对萎缩性胃炎和胃癌的诊断价值

Diagnostic Value of Serum Pepsinogen,Gastrin-17 and Helicobacter pylori Antibody for Atrophic Gastritis and Gastric Cancer

诸多研究表明,血清胃蛋白酶原(PG)和胃泌素-17(G-17)水平变化能反映胃黏膜组织学状态,可作为胃底腺黏膜的血清学活检,并可将血清PGⅠ水平和PGⅠ/PGⅡ比值(PGR)下降以及G-17水平升高作为胃癌高风险指标应用于临床评估。幽门螺杆菌(Hp)感染可导致慢性活动性胃炎,随着炎症进展,可引起黏膜萎缩、肠化生。本文就血清PG、G-17、Hp抗体检测对萎缩性胃炎和胃癌的诊断价值作一综述。

Numerous studies showed that changes in serum pepsinogen （PG） and gastrin-17 （G-17） levels can reflect histological condition of gastric mucosa, that can be served as serological biopsy of gastric fundic glandular mucosa. The decrease of serum PG I level and PG I/PG Ⅱ ratio （PGR） as well as increase of G-17 denotes a high risk of gastric cancer. Helicobacter pylori （Hp） infection can cause chronic active gastritis, and the progress of inflammation can lead to atrophy and intestinal metaplasia of mucosa. This article reviewed the diagnostic value of serum PG, G-17 and Hp antibody for atrophic gastritis and gastric cancer.