谷胱甘肽对氯化汞致果蝇肠损伤的影响

Effects of Glutathione on Mercuric Chloride-Induced Intestinal Damage in Drosophila

以模式生物果蝇为模型,研究了谷胱甘肽(1 mmol/L)对氯化汞(400μmol/L)致果蝇肠损伤的影响。结果表明,谷胱甘肽对氯化汞所致果蝇肠道损伤有一定的保护作用。1 mmol/L谷胱甘肽显著抑制400μmol/L氯化汞所致果蝇肠道上皮活性氧的产生、细胞凋亡以及肠道干细胞的分裂。

In this study, Drosophila melanogaster was taken as a model to investigate the effect of glutathione on the mercuric chloride-induced intestinal damage in Drosophila. The results showed that glutathione has protective effect on mercuric chloride-induced intestinal damage. It could significantly inhibit the reactive oxidative species generation, cellular apoptosis and intestinal stem cell division which induced by 400 μmol / L mercuric chloride with dose of 1 mmol / L.