口服胃肠超声造影对焦虑症患者胃动力的评价

Evaluation of oral gastrointestinal ultrasound contrast agents on gastric motility in patients with anxiety disorder

目的应用口服胃肠超声造影评价伴有功能性消化不良的焦虑症患者胃肠动力的异常。方法选取伴有上消化道症状但无器质性病变的焦虑症患者20例和健康对照20例，口服胃肠超声造影剂，测量各时间点的胃窦收缩频率、胃窦收缩幅度、胃窦动力指数（MI），计算胃排空率（GER），评价焦虑症患者的胃肠动力参数。结果焦虑症组胃窦收缩频率及MI在最初2min内与对照组比较差异无统计学意义。焦虑症组造影后5～30min内各时间点胃窦收缩幅度、胃窦收缩频率及MI均较对照组降低，差异有统计学意义（P〈0．05）。造影20min后，对照组GER明显高于焦虑症组，差异具有统计学意义（P〈0．05）。结论口服胃肠超声造影是一种经济、可操作性强，且无创、可重复性高的评价焦虑症患者胃肠动力异常的方法。

Objective To apply the oral gastrointestinal ultrasound contrast agents for evaluating the gastric motility abnormality in the patients with anxiety disorder. Methods Twenty patients with anxiety disorder complicating upper digestive tract symptoms without organic pathological changes were enrolled as the anxiety disorder group. Twenty healthy volunteers were enrolled as the control group in this study. The two groups orally took gastrointestinal ultrasound contrast agents. The antral contraction frequency,antral contraction amplitude amd MI were measured at each time point. GER was calculated. The the gastric motility parameters in the patients with anxiety disorder were evaluated. Results The antral contraction frequency and MI. at initial 2 rain had no statistical difference between the anxiety group and the control group. The antral contraction amplitude, antral contraction frequency amd MI at each time point during 5 - 10 min after contrast in the anxiety disorder group were significantly decreased compared with the control group, and the differences were statistically significant （P〈0.05）. After 20 min, GER in the control group was significantly higher than that in the anxiety group,the difference was statistically significant（P〈0. 05）. Conclusion Oral gastrointestinal ultrasound contrast agents is a economic, strongly operable,non-invasive and highly repeatable method for evaluating the gastric motility.