重组人干扰素α1b雾化吸入在急性毛细支气管炎患儿中的应用价值分析

The application of recombinant human interferon α1b in the treatment of children with acute bronchiolitis

目的观察重组人干扰素α1b雾化吸入治疗儿童急性毛细支气管炎的临床疗效。方法选取我院收治的急性毛细支气管炎患儿共127例,随机分为对照组(N=63)与观察组(N=64),两组患儿均接受急性毛细支气管炎相关治疗包括止咳、平喘、抗感染等措施。对照组患儿接受常规治疗,观察组患儿在常规治疗基础上给予重组人干扰素α1b雾化吸入治疗。比较两组治疗后主要及次要疗效指标消失时间、治疗效果等相关指标。结果观察组患儿主要及次要疗效指标如喘息、三凹征等消失时间均明显短于对照组,P<0.05。观察组患儿治疗总有效率为87.3%,明显高于对照组总有效率69.4%,P<0.05。观察组患儿早期(病程<72h)治疗后疗效指标总改善率高于晚期(病程≥72h)治疗患儿,P<0.05。且观察组呼吸道合胞病毒(RSV)阳性的患儿治疗疗效指标总改善率高于RSV阴性患儿,P<0.05。结论雾化吸入重组人干扰素α1b可以减轻儿童急性毛细支气管炎的临床症状、体征,缩短病程,对早期RSV阳性患儿治疗效果较好。

Objective To observe the clinical effect of recombinant human interferon α1 b atomization inha-lation in the treatment of children with acute bronchiolitis.Methods A total of 127 patients with acute bronchiolitis in our hospital were randomly divided into the control group （N =63）and the observation group （N =64）.All of them were treated with acute bronchiolitis treatment such as relieving cough and asthma,and anti-infection measures. The control group received conventional treatment,and the observation group was treated with recombinant human in-terferon α1b inhalation therapy based on conventional treatment.The main and secondary outcomes and related inde-xes such as disappearance time and treatment effect of the two groups were compared.Results The disappearance time of main and secondary effect in the observation group were significantly shorter than those of the control group,such as wheezing,three,and so on （P 〈0.05）.The total effective rate of the observation group was 87.3%,whichwas significantly higher than 69.4% of the control group （P 〈0.05）.The total improved rate was obviously higher inpatients at early course（course of disease 〈72h）than in patients at long course （≥72h）in the observation group （P〈0.05）.The total improvement rate of children with respiratory tract virus （RSV）positive in the observation groupwas higher than that of RSV negative （P 〈0.05）.Conclusion The recombinant human interferon α1b can relievethe clinical symptoms and signs of acute bronchiolitis in children,shorten the course of disease,and the treatmenteffect of early RSV positive children is better.