慢性阻塞性肺疾病患者lep-tin、IL-6的表达变化及其意义

The expression and significance of lep-tin and IL-6 in COPD patients

目的：观察慢性阻塞性肺疾病（慢阻肺）患者 lep-tin、IL-6的表达情况，并分析其变化的临床意义。方法选取2013年5月～2015年5月在我院呼吸内科治疗的80例慢阻肺患者为研究对象，其中急性加重期的患者40例（急性加重期组），稳定期患者40例（稳定期组），同时选取40例健康志愿者作为对照组。比较不同时期的慢阻肺患者与对照组患者血清中 lep-tin、IL-6含量、实验室指标以及肺功能指标的差异，采用Pearson 相关分析法分析 lep-tin、IL-6与实验室指标、肺功能的相关性。结果急性加重期和稳定期慢阻肺患者的 lep-tin、IL-6和 WBC、NEU％、CRP、PaCO2等实验室指标明显均高于对照组，PH、PaO2和 SaO2低于对照组；且急性加重期和稳定期患者的上述指标也存在明显差异；慢阻肺急性加重期和稳定期患者的肺功能均较差，且各项指标均低于对照组；急性加重期和稳定期慢阻肺患者的 lep-tin、IL-6与 WBC、NEU％、CRP、PaCO2呈正相关，与 PH、PaO2和 SaO2呈负相关；急性加重期和稳定期慢阻肺患者的 lep-tin、IL-6水平均与肺功能相关指标（6MWT、FVC、FEV1、FEV1／FVC、MMEF 和 PEF）均显著负相关。结论慢阻肺患者 lep-tin、IL-6的表达较健康者高，且急性加重期更甚；lep-tin、IL-6水平与 WBC、NEU％、CRP 等实验室相关指标显著正相关，与PH、PaO2、SaO2指标以及肺功能相关指标显著负相关。提示 lep-tin、IL-6水平对预测慢阻肺病情的严重程度有重要的指导意义。

Objective To investigate the expression of IL-6 and lep-tin in patients with COPD and the clini-cal significance of the changes.Methods 80 COPD patients treated in our hospital respiratory medicine from May 2013 to May 2015 were selected for the study,included 40 AECOPD cases as the acute group and 40 COPD patients at stable stage as the stable group,while another 40 cases of healthy volunteers were taken as the control group.The levels of lep -tin and IL -6,and pulmonary function laboratory parameters were compared among the different groups,and it used Pearson correlation to analyze the relationship of lep-tin and IL-6 to pulmonary function.Results The levels of lep-tin,IL-6 and WBC,NEU%,CRP,PaCO2 and other laboratory parameters in the acute exacerba-tion group and the stable group were significantly higher than those in the control group.The value of PH,PaO2 and SaO2 were lower in the COPD group than in the control group.There were also significant differences in the above in-dexes between the acute exacerbation group and the stable group.In COPD patients,the levels of lep-tin and IL-6 were positively correlated with WBC,NEU%,CRP and PaCO2 ,and negatively correlated with PH,PaO2 and SaO2 . The levels of lep-tin and IL-6 were negatively correlated lung function indicators （6MWT,FVC,FEV1 ,FEV1 /FVC, MMEF and PEF）.Conclusion The levels of lep-tin and IL-6 are higher in COPD patients than in healthy controls, and they are even higher in AECOPD patients.The levels of lep-tin and IL-6 are positively correlated with WBC, NEU%,CRP and other laboratory,and positively correlated with PH ,PaO2 ,SaO2 and lung function,which means they has an important prediction value on COPD severity.