乌司他丁联合生长抑素治疗重症胰腺炎疗效评价

The curative effect evaluation of Ulinastatin combined somatostatin treating severe acute pancreatitis

目的探讨乌司他丁联合生长抑素治疗重症急性胰腺炎的临床疗效。方法回顾性收集2013年1月~2015年1月收治的重症急性胰腺炎患者86例,将其分为观察组和对照组,观察组41例,在对症治疗基础上联合应用乌司他丁及生长抑素;对照组45例,在对症治疗基础上应用生长抑素。比较两组患者的临床疗效、临床症状及实验室指标恢复情况,并于出院后1、3、6个月随访患者,观察两组患者治疗后的生存质量。结果观察组治疗有效率明显高于对照组（P〈0.05）,观察组患者的腹膜刺激征持续时间、恶心、呕吐等症状持续时间及血、尿淀粉酶恢复正常时间均明显低于对照组（P〈0.05）。定期随访患者,治疗后第3个月、第6个月观察组患者的生存质量明显高于对照组（P〈0.05）。结论乌司他丁联合生长抑素治疗重症急性胰腺炎临床效果好,能在短期内缓解临床症状、提高生存质量,是治疗重症胰腺炎的较好选择方案。

Objective To study the clinical curative effect of ulinastatin combined somatostatin on treatment of the severe pancreatitis.Methods 86 patients of severe acute pancreatitis were divide into observation group and control group.The observation group（41cases）was treated with the combined use of somatostatin and ulinastatin based on the symptomatic treatment.The control group（45cases）was treated with somatostatin treatment based on the symptomatic treatment.The clinical curative effect,the recovery of clinical symptoms and laboratory indicators were observed.The quality of life of patients was followed-up at 1month,3months and 6months.Results The effective rate of observation group was obviously higher than that in control group（P0.05）.The duration time of patients＇ peritoneal irritation,nausea,vomiting and the blood and urine amylase returned to normal time in observation group were shorter than that in control（P0.05）.The patient quality life of observation group was obviously higher than that of control group.Conclusion It is effective to treat severe acute pancreatitis with ulinastatin combined somatostatin.ulinastatin combined somatostatin can help patients recover soon and lead to a high quality life after treatment.