醒脑静联合尼莫地平治疗血管性痴呆及对患者精神行为症状的影响

Xingnaojing combined with nimodipine in treatment of vascular dementia and intervention on behavioral and psychological symptoms

目的探讨醒脑静联合尼莫地平治疗血管性痴呆的疗效及其对患者精神行为症状的影响。方法将收治的血管性痴呆患者86例,按照简单数字表法随机分为对照组和观察组各43例。对照组给予尼莫地平治疗,观察组给予醒脑静注射液联合尼莫地平治疗。比较两组患者的临床治疗效果,并对患者精神行为症状的影响进行评价。结果观察组总有效率90.70%高于对照组的62.79%,差异具有统计学意义(P<0.05)。观察组患者简明智能状态检查量表(MMSE)评分(18.62±4.83)分和日常生活活动能力量表(ADL)评分(34.12±7.82)分均高于对照组患者的(15.75±4.60)分和(28.35±7.46)分,差异具有统计学意义(P<0.01)。观察组患者长谷川痴呆量表(HDS)评分(23.65±4.21)分高于对照组的(21.32±4.15)分,差异具有统计学意义(P<0.01)。观察组患者痴呆病理行为评定量表(BEHAVEAD)评分(11.84±4.08)分低于对照组患者的(13.92±4.23)分,差异具有统计学意义(P<0.01)。结论醒脑静注射液联合尼莫地平治疗血管性痴呆疗效显著,可有效改善患者认知功能和精神状态,提高患者生活质量,具有较好的临床应用价值。

Objective To investigate the effect of Xingnaojing injection combined with nimodipine in treatment of vascular dementia and intervention on behavioral and psychological symptoms.Methods 86 vascular dementia patients were randomly divided into control group（43cases）and observation group（43cases）.The control group was given nimodipine treatment and observation group were treated with Xingnaojing injection combined with nimodipine treatment.Results The total effective rate in observation group（90.70%）was higher than that in the control group（62.79%）with statistically significant difference（P0.05）.After treatment,MMSE score of the observation group（18.62±4.83）was higher than those in the control group（15.75±4.60）with significant difference（P0.01）.After treatment,ADL score of the observation group（34.12±7.82）was higher than those in the control group（28.35±7.46）with significant difference（P0.01）.After treatment,HDS score of the observation group（23.65±4.21）was higher than those in the control group（21.32±4.15）with significant difference（P0.01）.After treatment,BEHAVE-AD score of the observation group（11.84±4.08）was lower than that of the control group（13.92±4.23）with significant difference（P0.01）.Conclusion Xingnaojing injection combined with nimodipine in treatment of vascular dementia can effectively improve cognitive function,mental state and the quality of life.