他克莫司联合复方倍他米松对激素依赖性皮炎患者皮损评分及表皮含水量的影响

Influence of tacrolimus with betamethasone on skin lesions score and skin moisture content of hormone-dependent dermatitis

目的探讨他克莫司联合复方倍他米松对激素依赖性皮炎患者皮损评分及表皮含水量的影响。方法选取收治的80例面部激素依赖性皮炎患者,将其按随机数表法分为对照组和观察组,每组各40例。对照组患者采用他克莫司单独治疗,观察组患者采用他克莫司联合复方倍他米松治疗,均治疗4周后停药,停药后随访1个月。评价两组患者治疗后的疗效及不同时间点两组患者的皮损评分情况,测量两组患者不同时间点表皮角质层中含水量的变化情况,并进行比较。结果两组患者治疗4周后的总有效率分别为70.0%、90.0%,观察组总有效率明显高于对照组(2=5.00,P<0.05);两组患者治疗后的皮损评分较治疗前相比变化明显,治疗后不同时间点与治疗前比较均有统计学意义(P<0.05),且观察组患者治疗4周及停药1个月时的皮损评分较对照组低,比较差异具有统计意义(P<0.05);对照组治疗治疗4周、停药1个月时检测的表皮含水量较治疗前多(P<0.05),观察组患者治疗2周、4周及停药1个月时的表皮含水量较治疗前多,且明显多于对照组相应时间点的表皮含水量,比较差异具有统计学意义(P<0.05)。结论采用他克莫司联合复方倍他米松治疗激素依赖性皮炎患者的疗效优于他克莫司单独治疗,既能有效降低皮损评分,提高表皮含水量,使面部皮肤屏障功能明显改善,还具有较高的安全性,可在临床推广应用。

Objective To investigate the influence of tacrolimus with betamethasone on skin lesions score and skin moisture content of hormone-dependent dermatitis.Methods 80 patients with hormone-dependent facial dermatitis were randomly divided into control group and observation group,40 cases in each group.The control group was treated with tacrolimus.The observation group was treated with tacrolimus and betamethasone.The effect,skin lesions and skin moisture content were measured.Results The total effective rate of control group and observation group were 70.0%and 90.0%,respectively.After 4weeks treatment,the total effective rate of observation group was significantly higher than that of the control（2=5.00,P0.05）.The lesion score after treatment changed significantly compared to that before treatment（P0.05）at different time points.The skin moisture content of the two groups increased after treatment.The skin moisture content of observation group more significantly increased than that of control group（P0.05）..Conclusion Tacrolimus with betamethasone for patients with hormone-dependent dermatitis can effectively reduce the rate of skin lesions and improve skin moisture.