布地奈德雾化吸入联合麻杏石甘汤加减对肺炎高热小儿血清CRP影响及临床疗效研究

Effect of Serum CRP and Clinical Observation of Budesonide Inhalation Combined with Maxing Shigan Decoction in Children with Pneumonia

目的：探究布地奈德雾化吸入联合麻杏石甘汤对肺炎高热小儿血清CRP影响及临床疗效。方法：收集我院儿科收治的肺炎高热小儿78例,根据随机对照表分为对照组和试验组,其中试验组39例,对照组39例,2组均实施常规治疗以及对症治疗,对照组给予布地奈德雾化吸入2 mg,每日2次头孢地嗪钠（浙江永宁药业股份有限公司,国药准字H20113040）80 mg/（kg·d）静脉滴注,分2次;试验组在对照组的基础上给予麻杏石甘汤联合治疗,30～100 m L,每日3次,每8 h 1次。2组患儿1个周期为7 d,共治疗2个周期。治疗结束后对比分析2组临床疗效、主要临床症状和体征消失时间、CRP、NT-pro BNP、WBC、GRAN、MON、%GRAN、%LYM等血生化指标以及不良反应。结果：治疗后,与对照组相比,试验组临床总有效率较高（P〈0.05）,主要临床症状和体征消失时间均缩短（P〈0.05）,血清CRP、NT-pro BNP水平较低（P〈0.05）,WBC、GRAN、MON、%GRAN、%LYM等血生化指标均较低（P〈0.05）,试验组不良反应发生率为7.69%,显著低于对照组15.38%（P〈0.05）。结论：布地奈德雾化吸入联合麻杏石甘汤对肺炎高热小儿的临床疗效显著,显著降低血清CRP水平,安全性高。

Objective ： To investigate effect of serum CRP and clinical effect of budesonide inhalation combined with Maxing shigan Decoction in children with pneumonia. Method： 78 children with pneumonia from our hospital department of pediatrics were selected and randomly divided into the control group and the experiment group with 39 cases in each group. Routine treatment and symptomatic treatment were carried out in the 2 groups. The control group were treated by budesonide and erythromycin lactobionate and the experiment group were treated on the base of the control group with Maxing Shigan Decoction. 2 groups of children with a cycle of 7 d, a total of 2 cycles of treatment. The clinical efficacy, main clinical symptoms, signs disappeared time, CRP, NT-proBNP, WBC, GRAN, MON, %GRAN, %LYM level and adverse reactions were compared. Result： Compared with the control group, the clinical total effective rate were higher （ P〈0.05 ）, the disappearance time of main clinical symptoms and signs were shorter （ P〈0.05 ）, the WBC, GRAN, MON, %GRAN and %LYM levels were lower （ P〈0.05 ）. The incidence of adverse reactions in the experimental group was 7.69%, significantly lower than that of the control group 15.38% （ P〈0.05 ）. Conclusion ： Budesonide atomization inhalation combined with Maxing Shigan on pneumonia in children with high fever clinical curative effect is distinct, serum CRP levels were significantly reduced, the safety is high.