肿瘤标志物CA19-9、CEA、CA242、CA125和AFP评估胃癌化疗疗效的检验分析

Test analysis on tumor marker CA19-9,CEA,CA242,CA125 and AFP in assessing efficacy of chemotherapy in gastric cancer

目的探讨肿瘤标志物CA19-9、癌胚抗原（CEA）、CA242、CA125和甲胎蛋白（AFP）联合评估胃癌化疗疗效的检验分析。方法选取2010年1月至2013年12月该院收治的胃癌患者160例作为研究对象。分别检测患者治疗前和治疗后3个月相关肿瘤标志物的表达情况。并分析患者TNM分期与肿瘤标志物的关系,治疗前后肿瘤标志物的变化,复发转移与未复发转移患者体内肿瘤标志物的变化关系。结果不同TNM分期与相关肿瘤标志物的阳性表达率有显著相关性。Ⅲ期和Ⅳ期的患者相关肿瘤标志物的阳性表达率显著高于Ⅰ~Ⅱ期。患者经过化疗后CA19-9、CA242、CA125和AFP水平与治疗前相比均显著下降（P〈0.05）,CEA水平治疗前后差异无统计学意义（P〉0.05）。经过治疗后,患者CEA、CA19-9、CA242、CA125以及AFP阳性表达率均下降,且与治疗前相比,差异有统计学意义（P〈0.05）。在复发转移患者与未复发转移患者血清相关肿瘤标志物的比较表明,复发转移患者的CEA、CA19-9、CA242、CA124和AFP水平均显著高于未复发转移组（P〈0.05）。结论 CA19-9、CEA、CA242、CA125和AFP与肿瘤患者TNM分期有着显著相关性,其表达水平以及阳性表达率与胃癌患者预后具有一定的相关性,值得临床重点关注。

Objective To investigate the test analysis of tumor marker CA19-9,CEA,CA242,CA125 and AFP for jointly assessing the chemotherapeutic effect of gastric cancer.Methods Totally 160 patients with gastric cancer in our hospital from January2010 to December 2013 were selected as the research subjects.The expressions of related tumor markers were detected before treatment and at 3months after treatment.The relationship between the TNM staging and the tumor markers,changes of tumor markers before and after treatment,and changes of tumor markers in the patients with recurrence and metastasis,and patients without recurrence and metastasis were analyzed.Results Different TNM staging had significant correlation with tumor markers associated positive expression rate.The positive expression rate of related tumor markers in the patients with stageⅢ and stageⅣ were significantly higher than that in the patients with stageⅠ-Ⅱ.The positive expression rates of CA19-9,CA242,CA125 and AFP after chemotherapy were significantly decreased compared with before treatment（P〈0.05）,while the CEA level had no statistically significant difference before and after treatment（P〉0.05）.After treatment,the CEA,CA19-9,CA242,CA125 and AFP positive expression rates were declined,moreover showing statistical differences compared with pre-treatment（P〈0.05）.The CEA,CA19-9,CA242,CA124 and AFP levels in the patients with recurrence and metastasis were significantly higher than those in the patients without recurrence and metastasis（P〈0.05）.Conclusion CA19-9,CEA,CA242,CA125 and AFP have a significant correlation with tumor TNM staging,their expression level and positive expression rates have certain correlation with the prognosis in the patients with gastric cancer,which is worthy of focus in clinic.